{"id":"W2092414507","doi":"10.4161/cc.5.13.2922","title":"Phenotypic Activation to Discover Biological Pathways and Kinase Substrates","year":2006,"lang":"en","type":"article","venue":"Cell Cycle","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Biotechnology and Biological Sciences Research Council","keywords":"Biology; Phenotype; Kinase; Signal transduction; Cell biology; Computational biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005108668,0.00008281028,0.00006226508,0.00001272886,0.00005352258,0.00002826924,0.00005767356,0.00008911299,0.00001198832],"category_scores_gemma":[0.000004271624,0.00006853455,0.00002351351,0.00003428513,0.00002919156,0.000003156433,0.00005628441,0.00003832608,0.00001596882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004995065,"about_ca_system_score_gemma":0.0000112899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002360324,"about_ca_topic_score_gemma":0.00001285964,"domain_scores_codex":[0.9995608,0.000009353581,0.0001057255,0.0001476108,0.00003260319,0.0001438915],"domain_scores_gemma":[0.999781,0.000005710493,0.00003041707,0.0001221689,0.00001364887,0.00004703198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003853137,0.00004819717,0.002082383,0.00000957615,0.000004379373,6.557552e-7,0.00003655814,0.0004377601,0.9909638,0.0007489585,0.00233681,0.003292382],"study_design_scores_gemma":[0.0006250729,0.0003062587,0.04853654,0.00001002601,0.000007808967,0.000003111675,0.0001110986,0.000675404,0.9228082,0.005146203,0.0214011,0.0003691856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917786,0.0002037477,0.002754259,0.00005998037,0.00004123728,0.00009959715,0.00000909145,0.000007593211,0.005045934],"genre_scores_gemma":[0.9985962,0.0000231966,0.0006132321,0.0002429763,0.0001747101,0.000007041948,0.0001177284,0.000006871425,0.0002180435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06815562,"threshold_uncertainty_score":0.2794758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007668081059949052,"score_gpt":0.1937809679167151,"score_spread":0.1861128868567661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}