{"id":"W2092414507","doi":"10.4161/cc.5.13.2922","title":"Phenotypic Activation to Discover Biological Pathways and Kinase Substrates","year":2006,"lang":"en","type":"article","venue":"Cell Cycle","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Biotechnology and Biological Sciences Research Council","keywords":"Biology; Phenotype; Kinase; Signal transduction; Cell biology; Computational biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002781031,0.0004272859,0.0003534628,0.0006962167,0.0002098837,0.0005449979,0.0003208374,0.0002304415,0.002939067],"category_scores_gemma":[0.0004309544,0.0001547156,0.0003421747,0.000731774,0.0002087228,0.0004342864,0.000466932,0.0007074836,0.001323409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002844426,"about_ca_system_score_gemma":0.0002248874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002010241,"about_ca_topic_score_gemma":0.000472806,"domain_scores_codex":[0.9998761,0.00002012597,0.000008131194,0.00003494244,0.00004655854,0.00001412342],"domain_scores_gemma":[0.9997903,0.00007527892,0.000039017,0.00004218144,0.00002789483,0.00002540703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001093612,0.00004427278,0.001723553,0.0001598669,0.0000181286,0.000135733,0.00001630787,0.0007042224,0.9693704,0.002685599,0.0005476684,0.02448482],"study_design_scores_gemma":[0.00003229354,0.0001734713,0.01347743,0.00001686651,0.00006389233,0.0008530188,0.00006181381,0.008972726,0.9391172,0.004387549,0.03282246,0.00002134729],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6514488,0.006223029,0.2893461,0.002558951,0.0002411679,0.0002968898,0.01277923,0.003821227,0.03328466],"genre_scores_gemma":[0.8256937,0.008107509,0.14288,0.0007836805,0.00008362436,0.0003504103,0.0100844,0.0003129561,0.01170369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002939067,"threshold_uncertainty_score":0.009832203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007668081059949052,"score_gpt":0.1937809679167151,"score_spread":0.1861128868567661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}