{"id":"W2092422626","doi":"10.1152/japplphysiol.01101.2013","title":"Reduced skeletal muscle AMPK and mitochondrial markers do not promote age-induced insulin resistance","year":2014,"lang":"en","type":"article","venue":"Journal of Applied Physiology","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"AMPK; Skeletal muscle; Endocrinology; Insulin resistance; Internal medicine; AMP-activated protein kinase; Glucose uptake; Mitochondrion; Protein kinase A; Biology; Mitochondrial ROS; Insulin; Chemistry; Cell biology; Phosphorylation; Medicine; Oxidative stress","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001685397,0.0003048131,0.0002922904,0.0004442887,0.00008948475,0.0002835015,0.0002315674,0.0003818903,0.001444185],"category_scores_gemma":[0.0001939021,0.0001761991,0.0002600342,0.0001740811,0.0002738898,0.0003773288,0.0002506884,0.0005940064,0.0002855923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001413778,"about_ca_system_score_gemma":0.00009020071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001870278,"about_ca_topic_score_gemma":0.0003809604,"domain_scores_codex":[0.9998671,0.00001711608,0.00001462311,0.00004463373,0.00003397758,0.00002250455],"domain_scores_gemma":[0.9994992,0.00002761073,0.0002818419,0.00004635521,0.0000371459,0.0001078736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005881402,0.0001106073,0.003953049,0.00005234313,0.0000287917,0.000143951,0.00002336326,0.00003236326,0.9922379,0.0001215778,0.00006970646,0.002638263],"study_design_scores_gemma":[0.0001211946,0.005039589,0.4501352,0.00007331083,0.0002385413,0.004080654,0.0001630311,0.0007870443,0.5317515,0.0005168873,0.007066059,0.00002700571],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994419,0.002262765,0.001725203,0.000112703,0.00003964037,0.00001549975,0.000344368,0.0000756224,0.001005312],"genre_scores_gemma":[0.9924067,0.001403284,0.001304254,0.0001625785,0.00002597874,0.00003979027,0.0007928197,0.00003830829,0.003826358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001444185,"threshold_uncertainty_score":0.004831314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00684559139672272,"score_gpt":0.2273075045148234,"score_spread":0.2204619131181007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}