{"id":"W2092435554","doi":"10.1038/mt.2010.264","title":"Adaptive Antiviral Immunity Is a Determinant of the Therapeutic Success of Oncolytic Virotherapy","year":2010,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Virotherapy; Oncolytic virus; Virology; Immunity; Biology; Acquired immune system; Immunology; Virus; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004821105,0.0002778828,0.0003262013,0.00008092852,0.0001081336,0.00001706053,0.001032133,0.0002310752,0.00009549068],"category_scores_gemma":[0.00002135948,0.000199637,0.000378292,0.0003046728,0.000568951,0.000006910214,0.0001293536,0.0003548028,0.000004421915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001248029,"about_ca_system_score_gemma":0.0002590897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001001579,"about_ca_topic_score_gemma":0.0001402948,"domain_scores_codex":[0.9981124,0.0003693584,0.0003647849,0.000364619,0.0004264772,0.0003623778],"domain_scores_gemma":[0.9980606,0.00002984169,0.0002485255,0.001381425,0.0002191636,0.00006044479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002163486,0.0002624212,0.00207413,0.00000986704,0.0002235037,0.000002501488,0.0002106783,0.000008183771,0.9560605,0.00007030406,0.00001754385,0.03889683],"study_design_scores_gemma":[0.001533389,0.002903736,0.005151613,0.00001683225,0.00001437741,0.000007326516,0.00003870008,0.00009805639,0.9882507,0.0003611106,0.00140451,0.0002196573],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965189,0.001588304,0.0004842407,0.0001869492,0.0001457277,0.0006649581,0.00003462177,0.000008572256,0.0003677442],"genre_scores_gemma":[0.9982712,0.0004861319,0.0001671698,0.0007310529,0.00005425218,0.00004663136,0.000007427536,0.00006511636,0.0001709693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03867717,"threshold_uncertainty_score":0.8140959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01719570671886764,"score_gpt":0.3043979316174504,"score_spread":0.2872022248985827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}