{"id":"W2092435554","doi":"10.1038/mt.2010.264","title":"Adaptive Antiviral Immunity Is a Determinant of the Therapeutic Success of Oncolytic Virotherapy","year":2010,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Virotherapy; Oncolytic virus; Virology; Immunity; Biology; Acquired immune system; Immunology; Virus; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005963214,0.0002143342,0.0003721116,0.0002314292,0.000115363,0.0006327001,0.0001714594,0.0004111105,0.001682359],"category_scores_gemma":[0.0012334,0.0001137249,0.0001035887,0.0001037628,0.000304796,0.0002833304,0.0002461007,0.0008840519,0.0003139988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000273526,"about_ca_system_score_gemma":0.0001766178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009074034,"about_ca_topic_score_gemma":0.00008433851,"domain_scores_codex":[0.9994636,0.0001555637,0.00005749658,0.00005592565,0.0001196216,0.0001477917],"domain_scores_gemma":[0.9991467,0.0004186629,0.0001783675,0.00006436724,0.00008178854,0.0001100215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006783592,0.0002569323,0.0113657,0.0001194327,0.00002889,0.0001381436,0.00007147181,0.0009958762,0.9576856,0.0009493319,0.0002576385,0.02745252],"study_design_scores_gemma":[0.00009361986,0.004356827,0.08322401,0.0000742655,0.000117546,0.002097137,0.0001980944,0.00975788,0.8889801,0.001674345,0.009396626,0.00002954376],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877207,0.004195226,0.003170298,0.0002547461,0.00003848453,0.00005681866,0.0000838788,0.00008765853,0.004392279],"genre_scores_gemma":[0.9987363,0.0003982422,0.0004120724,0.00003916863,0.00001998032,0.00001746841,0.00002800452,0.000008837521,0.0003398737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001682359,"threshold_uncertainty_score":0.005628109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01719570671886764,"score_gpt":0.3043979316174504,"score_spread":0.2872022248985827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}