{"id":"W2092459005","doi":"10.1371/journal.pone.0085937","title":"Inverse Agonism of SQ 29,548 and Ramatroban on Thromboxane A2 Receptor","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital Research Institute of Manitoba; University of Manitoba; Research Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Manitoba Medical Service Foundation; National Heart, Lung, and Blood Institute; Manitoba Health Research Council","keywords":"Inverse agonist; G protein-coupled receptor; Receptor; Pathophysiology; Platelet; Thromboxane; Pharmacology; Internal medicine; Platelet activation; Endocrinology; Agonist; Chemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000209497,0.0002562018,0.000525167,0.0001552448,0.00009119583,0.0002180549,0.0003098164,0.0002711665,0.002425628],"category_scores_gemma":[0.0002006145,0.0001421385,0.000381599,0.000142576,0.0002201084,0.0002331365,0.0001991975,0.001083973,0.0005186559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001514716,"about_ca_system_score_gemma":0.0001599081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003789008,"about_ca_topic_score_gemma":0.0006152499,"domain_scores_codex":[0.9998072,0.00004270719,0.00002703904,0.00004014162,0.00004466572,0.00003819197],"domain_scores_gemma":[0.9999366,0.00001870221,0.00001338506,0.000008850859,0.000008138294,0.00001437581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008428979,0.0001558767,0.0001792125,0.00009536821,0.00002218838,0.0001256125,0.00003147625,0.0001217755,0.9952749,0.0001339278,0.0001359897,0.002880833],"study_design_scores_gemma":[0.000535124,0.006260793,0.006505875,0.00002019024,0.000112316,0.001108513,0.0001165891,0.002417015,0.9773581,0.0001406857,0.00539961,0.00002509127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951599,0.001301137,0.0008630795,0.0001897511,0.00006184039,0.00004443119,0.0003851945,0.00005503798,0.001939677],"genre_scores_gemma":[0.9939882,0.001440573,0.001923434,0.0001733671,0.00002268833,0.00005555952,0.0006786945,0.00001627122,0.001701339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002425628,"threshold_uncertainty_score":0.008114576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02187039893871683,"score_gpt":0.2091372841577954,"score_spread":0.1872668852190786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}