{"id":"W2092463127","doi":"10.1002/cbic.201100634","title":"Substitution of a Conserved Disulfide in the Type IIa Bacteriocin, Leucocin A, with <scp>L</scp>‐Leucine and <scp>L</scp>‐Serine Residues: Effects on Activity and Three‐Dimensional Structure","year":2011,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Leucine; Serine; Disulfide bond; Substitution (logic); Stereochemistry; Bacteriocin; Chemistry; Bridge (graph theory); Peptide; Biochemistry; Amino acid; Biology; Computer science; Enzyme; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001183164,0.0002745908,0.0002705475,0.00004057878,0.00007336822,0.00002081936,0.0001474337,0.0002622604,0.000003556008],"category_scores_gemma":[0.0003280342,0.0001821203,0.00003778178,0.0001787467,0.0002613533,0.00001583352,0.00009911963,0.0002017299,6.553202e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001282119,"about_ca_system_score_gemma":0.00004774623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007173687,"about_ca_topic_score_gemma":0.0001148876,"domain_scores_codex":[0.9988881,0.00006013426,0.0001944465,0.0004515203,0.0001624456,0.000243398],"domain_scores_gemma":[0.999235,0.0001170781,0.0001548704,0.0003075074,0.00009803489,0.00008752161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000185535,0.00004547253,0.02285849,0.0001460404,0.00004142195,0.00000612078,0.000208711,5.692939e-7,0.9760272,0.00006008259,0.00008854486,0.0003317939],"study_design_scores_gemma":[0.0006426657,0.0003717828,0.3532609,0.00005684829,0.00002417296,0.00003001893,0.00003605137,0.00001187046,0.6453276,0.00009362479,0.0000955042,0.00004896515],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989203,0.0004713757,0.00001588631,0.00004815051,0.00005169963,0.0002995715,0.00003347019,0.00001119758,0.0001483505],"genre_scores_gemma":[0.9990809,0.00007544506,0.0002256533,0.0001804965,0.00009082266,0.00001149501,0.0002384042,0.00001851889,0.00007828498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3306996,"threshold_uncertainty_score":0.7426652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0101926308561351,"score_gpt":0.2038193013885254,"score_spread":0.1936266705323902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}