{"id":"W2092463127","doi":"10.1002/cbic.201100634","title":"Substitution of a Conserved Disulfide in the Type IIa Bacteriocin, Leucocin A, with <scp>L</scp>‐Leucine and <scp>L</scp>‐Serine Residues: Effects on Activity and Three‐Dimensional Structure","year":2011,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Leucine; Serine; Disulfide bond; Substitution (logic); Stereochemistry; Bacteriocin; Chemistry; Bridge (graph theory); Peptide; Biochemistry; Amino acid; Biology; Computer science; Enzyme; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001392047,0.0002547899,0.0001561377,0.0001119648,0.000121951,0.0002410388,0.0002381082,0.000273459,0.000946139],"category_scores_gemma":[0.0001938138,0.0001238227,0.0002297471,0.0001970529,0.0002491408,0.0001548131,0.0001675329,0.0003407225,0.000225544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002534396,"about_ca_system_score_gemma":0.0002466753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009948869,"about_ca_topic_score_gemma":0.001049164,"domain_scores_codex":[0.9998962,0.0000307334,0.00001453838,0.00001403357,0.00002722652,0.00001731247],"domain_scores_gemma":[0.999862,0.00004021579,0.00004292706,0.00001592123,0.000008615151,0.00003035253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005085152,0.0000602466,0.0001758978,0.00003101578,0.00001195742,0.000218482,0.00001461986,0.0001217399,0.9975726,0.0001149915,0.0000409456,0.00112893],"study_design_scores_gemma":[0.00004934848,0.0003881259,0.001801379,0.000003967227,0.00001929724,0.0004367431,0.00002655743,0.0008313243,0.9955578,0.0000300189,0.0008495218,0.000005850274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987488,0.0001182651,0.0004933681,0.00004046268,0.00001901696,0.00001064473,0.0001238548,0.00001035105,0.0004351989],"genre_scores_gemma":[0.9980358,0.000100676,0.0007994628,0.0000206017,0.000004528377,0.000005912485,0.0002359443,0.000009452776,0.0007876547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009948869,"threshold_uncertainty_score":0.003165126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0101926308561351,"score_gpt":0.2038193013885254,"score_spread":0.1936266705323902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}