{"id":"W2092463285","doi":"10.1016/j.virol.2010.08.025","title":"Nonstructural protein 1α subunit-based inhibition of NF-κB activation and suppression of interferon-β production by porcine reproductive and respiratory syndrome virus","year":2010,"lang":"en","type":"article","venue":"Virology","topic":"Animal Virus Infections Studies","field":"Agricultural and Biological Sciences","cited_by":117,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"Cooperative State Research, Education, and Extension Service; U.S. Department of Agriculture","keywords":"Biology; Porcine reproductive and respiratory syndrome virus; Interferon; Protein subunit; NF-κB; IκBα; Interferon type I; Downregulation and upregulation; Tumor necrosis factor alpha; NFKB1; Interferon regulatory factors; Phosphorylation; Signal transduction; Nuclear export signal; Molecular biology; Cell biology; Virology; Gene; Virus; Cell nucleus; Cytoplasm; Transcription factor; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002161399,0.0001075746,0.000195327,0.00003800157,0.0001288753,0.000004997094,0.00003886416,0.0001224801,0.00004697768],"category_scores_gemma":[0.0002220703,0.00005042076,0.00002087133,0.0001622982,0.0004649081,0.0001463959,0.0000630427,0.0001718384,7.190866e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009441717,"about_ca_system_score_gemma":0.000005556685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002916439,"about_ca_topic_score_gemma":0.0002613766,"domain_scores_codex":[0.9991699,0.00009987851,0.0002203379,0.0003166125,0.00008161529,0.0001116832],"domain_scores_gemma":[0.9995298,0.00005753208,0.0002089129,0.00006766943,0.0001096896,0.00002639216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000260971,0.00005632802,0.005864532,0.00001685838,0.000008619309,4.624128e-7,0.00004695481,7.72912e-7,0.990325,0.00007400606,0.0000769226,0.003268562],"study_design_scores_gemma":[0.000128931,0.001181521,0.2245847,0.00001775622,0.000008775438,0.00001765114,0.0000677792,0.000006435476,0.7735133,0.0002070228,0.0001989844,0.00006711764],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986702,0.00005649906,0.000006849219,0.0007541649,0.00009459887,0.0003325464,0.00002947585,0.00002362957,0.00003207096],"genre_scores_gemma":[0.9997598,0.000005650883,0.00007289534,0.00003351819,0.00006276909,0.00002647971,0.00001943579,0.000001280125,0.00001814971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2187202,"threshold_uncertainty_score":0.2056099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01185627317873121,"score_gpt":0.2155771046062825,"score_spread":0.2037208314275513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}