{"id":"W2092463285","doi":"10.1016/j.virol.2010.08.025","title":"Nonstructural protein 1α subunit-based inhibition of NF-κB activation and suppression of interferon-β production by porcine reproductive and respiratory syndrome virus","year":2010,"lang":"en","type":"article","venue":"Virology","topic":"Animal Virus Infections Studies","field":"Agricultural and Biological Sciences","cited_by":117,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"Cooperative State Research, Education, and Extension Service; U.S. Department of Agriculture","keywords":"Biology; Porcine reproductive and respiratory syndrome virus; Interferon; Protein subunit; NF-κB; IκBα; Interferon type I; Downregulation and upregulation; Tumor necrosis factor alpha; NFKB1; Interferon regulatory factors; Phosphorylation; Signal transduction; Nuclear export signal; Molecular biology; Cell biology; Virology; Gene; Virus; Cell nucleus; Cytoplasm; Transcription factor; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002710182,0.0004919425,0.000322368,0.0002231473,0.0002094197,0.000319272,0.0004116414,0.0002894395,0.001337971],"category_scores_gemma":[0.0001781242,0.000196396,0.000490433,0.0001463043,0.0003220031,0.0002059579,0.0001550893,0.0007393013,0.0003218692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000292062,"about_ca_system_score_gemma":0.0002634995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006103982,"about_ca_topic_score_gemma":0.0005809435,"domain_scores_codex":[0.9998323,0.00003846393,0.00001819998,0.00001900723,0.00002904548,0.00006295514],"domain_scores_gemma":[0.9999106,0.00002403784,0.00001756481,0.00001818858,0.000007899911,0.00002180004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001000291,0.0001698747,0.0001048663,0.00004930108,0.00001253653,0.00004165722,0.00001566123,0.0001536178,0.9969168,0.0001152902,0.00006246367,0.001357749],"study_design_scores_gemma":[0.0001676835,0.001737512,0.002775373,0.000007741121,0.0000339067,0.0002266799,0.00003191899,0.001082962,0.9922699,0.00007472385,0.001584979,0.000006530076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968561,0.001088077,0.0008441979,0.00006732308,0.00009408996,0.00002684153,0.0001242208,0.000039773,0.0008593968],"genre_scores_gemma":[0.9970253,0.000645857,0.0007452614,0.0000446415,0.00002097834,0.00002809839,0.0004815042,0.00001132368,0.0009969482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001337971,"threshold_uncertainty_score":0.004475951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01185627317873121,"score_gpt":0.2155771046062825,"score_spread":0.2037208314275513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}