{"id":"W2092469155","doi":"10.1021/bi100378m","title":"Probing the “Charge Cluster Mechanism” in Amphipathic Helical Cationic Antimicrobial Peptides","year":2010,"lang":"en","type":"article","venue":"Biochemistry","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":153,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; McMaster University Medical Centre","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Magainin; Antimicrobial peptides; Amphiphile; Chemistry; Cationic polymerization; Peptide; Antimicrobial; Biochemistry; Membrane lipids; Membrane; Combinatorial chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002396103,0.0002134654,0.000165175,0.0002028749,0.0001467251,0.0002349738,0.0002104933,0.0003118612,0.0003364532],"category_scores_gemma":[0.0002803756,0.0001250603,0.0001546751,0.0001157437,0.0002886499,0.0003146203,0.0002044028,0.0003151216,0.0001379091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002750034,"about_ca_system_score_gemma":0.0001312742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004007163,"about_ca_topic_score_gemma":0.0003414493,"domain_scores_codex":[0.9998661,0.00003092417,0.000007360083,0.00002380061,0.00004653889,0.00002527589],"domain_scores_gemma":[0.9998143,0.00005849376,0.00005104291,0.000011276,0.00003333163,0.00003154302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004721032,0.00000781298,0.0002094201,0.00001658171,0.00000304669,0.00001675713,0.00001278043,0.0001720911,0.999054,0.00004781368,0.000005085424,0.0004074346],"study_design_scores_gemma":[0.000007214403,0.0002066691,0.002750274,0.000003245596,0.000005765697,0.00009247355,0.00002556065,0.002306281,0.9942951,0.00006070495,0.0002411522,0.000005437347],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968358,0.000272732,0.002510812,0.00002367559,0.000003474016,0.00002066911,0.00002339113,0.00001783082,0.00029178],"genre_scores_gemma":[0.9968861,0.0001901713,0.002442867,0.00003801895,0.000002652535,0.00002040364,0.00004554384,0.000006193546,0.0003680693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004007163,"threshold_uncertainty_score":0.001995265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008023528907358402,"score_gpt":0.2198620425687656,"score_spread":0.2118385136614072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}