{"id":"W2092472911","doi":"10.1016/j.biomaterials.2012.03.023","title":"Therapeutic effect of orally administered microencapsulated oxaliplatin for colorectal cancer","year":2012,"lang":"en","type":"article","venue":"Biomaterials","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Alnylam Pharmaceuticals","keywords":"Oxaliplatin; Colorectal cancer; Medicine; Drug delivery; Gastrointestinal tract; Cancer; Pharmacology; In vivo; Oral administration; Adverse effect; Drug; Oncology; Internal medicine; Materials science; Nanotechnology; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001155482,0.0002380902,0.0005135244,0.00007259333,0.00008181809,0.00006203401,0.0002478195,0.0001210033,0.0009341641],"category_scores_gemma":[0.00009503168,0.0001840768,0.0001051157,0.0001375393,0.0001300084,0.0002307391,0.00006460316,0.000007728204,0.0001421478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006442901,"about_ca_system_score_gemma":0.00007083117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001125773,"about_ca_topic_score_gemma":0.000007000773,"domain_scores_codex":[0.9980875,0.0003250184,0.0005537521,0.0002596886,0.000198928,0.0005750895],"domain_scores_gemma":[0.9989133,0.0002884673,0.0003246921,0.0002487927,0.00009522858,0.0001294572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001412431,0.0000952171,0.002725788,0.0001883374,0.00003372744,9.706e-7,0.000184532,0.000002487196,0.994659,0.00005202676,0.000271249,0.0003742104],"study_design_scores_gemma":[0.00140987,0.0005993603,0.003740977,0.00005415374,0.000105849,0.000006505965,0.00001027359,0.00002078686,0.9934199,0.00002026743,0.000399089,0.0002129749],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954973,0.0005160396,0.00003646549,0.00006301015,0.002216857,0.001011736,0.0005196694,0.0001210726,0.00001787884],"genre_scores_gemma":[0.9986485,0.00000519178,0.0006609817,0.00006037828,0.0002350165,0.0002817942,0.00003013227,0.00003992862,0.00003806701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003151239,"threshold_uncertainty_score":0.9999791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02315836411872257,"score_gpt":0.3010808897662177,"score_spread":0.2779225256474951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}