{"id":"W2092501359","doi":"10.1371/journal.pone.0046055","title":"Lovastatin Induces Multiple Stress Pathways Including LKB1/AMPK Activation That Regulate Its Cytotoxic Effects in Squamous Cell Carcinoma Cells","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Canadian Institutes of Health Research; Prostate Cancer Fight Foundation; AstraZeneca","keywords":"AMPK; Lovastatin; Cytotoxic T cell; Cancer research; Basal cell; Cell growth; Cell biology; Chemistry; Biology; Medicine; Internal medicine; Protein kinase A; Kinase; Cholesterol; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007589304,0.0003042899,0.0003992589,0.0002811771,0.000257508,0.0003418843,0.0001141538,0.0002411836,0.00148768],"category_scores_gemma":[0.00006448948,0.0001165971,0.0003801463,0.0002465204,0.000133983,0.0001489413,0.0001318546,0.0003736501,0.0004208138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004246131,"about_ca_system_score_gemma":0.0002978718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001223223,"about_ca_topic_score_gemma":0.002548854,"domain_scores_codex":[0.9998782,0.00001670983,0.00001828856,0.00002231067,0.00002965436,0.00003485764],"domain_scores_gemma":[0.9999558,0.000005521639,0.0000113877,0.00000612952,0.000009755139,0.00001131176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004220414,0.00006155747,0.0005238358,0.0001238889,0.00001676566,0.00008782819,0.00002021773,0.00004745908,0.9963295,0.00004606138,0.0001198048,0.002201166],"study_design_scores_gemma":[0.00003777634,0.0005295227,0.008808739,0.00001159134,0.00004695557,0.0003300775,0.00006117419,0.0003130546,0.9849819,0.00004259331,0.004830661,0.000005893315],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822348,0.01182471,0.001490814,0.0002325281,0.0001193772,0.00008252554,0.001009914,0.0001309436,0.00287431],"genre_scores_gemma":[0.9935772,0.002557433,0.0008758972,0.00008738443,0.00001698941,0.00005516662,0.0007719779,0.00001136571,0.002046687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00148768,"threshold_uncertainty_score":0.004976749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04396933149493912,"score_gpt":0.2306582279351483,"score_spread":0.1866888964402091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}