{"id":"W2092512352","doi":"10.1210/me.2009-0254","title":"Physiological Genomics Identifies Estrogen-Related Receptor α as a Regulator of Renal Sodium and Potassium Homeostasis and the Renin-Angiotensin Pathway","year":2009,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute; McGill University Health Centre","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Homeostasis; Endocrinology; Biology; Internal medicine; Renin–angiotensin system; Angiotensin II; Kidney; Receptor; Energy homeostasis; Regulator; Glucose homeostasis; Estrogen-related receptor alpha; Estrogen receptor; Blood pressure; Medicine; Diabetes mellitus; Gene; Biochemistry; Insulin resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001188946,0.0001547212,0.0002229773,0.0001845414,0.0001179141,0.0002427431,0.0001355519,0.0001441169,0.0005893787],"category_scores_gemma":[0.0000966167,0.0001118606,0.0001341532,0.0001257359,0.0001547876,0.0001294827,0.000153013,0.0002160769,0.0001835025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001746822,"about_ca_system_score_gemma":0.0001515341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005041204,"about_ca_topic_score_gemma":0.0004507423,"domain_scores_codex":[0.9999229,0.00001454809,0.000003578324,0.00002667108,0.0000189095,0.00001333501],"domain_scores_gemma":[0.9999348,0.00001095056,0.00002210114,0.000006850441,0.00001155652,0.00001376419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000218559,0.0000175753,0.003124114,0.00002735185,0.00001529337,0.0002814312,0.0000296197,0.0002600975,0.9872256,0.0007086354,0.00009321172,0.007998539],"study_design_scores_gemma":[0.0001186521,0.0009814642,0.5031334,0.00004425086,0.0002106753,0.006063404,0.0003170923,0.006694428,0.4521307,0.004523075,0.02573262,0.00005017762],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979916,0.004633156,0.009758065,0.000632546,0.00004344139,0.00001306649,0.0005034013,0.00009956073,0.00440083],"genre_scores_gemma":[0.9908906,0.002173043,0.003754896,0.0001674321,0.00003128564,0.000008380111,0.0004686864,0.00001396329,0.002491665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005893787,"threshold_uncertainty_score":0.001971662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006046374576326123,"score_gpt":0.2102337500835647,"score_spread":0.2041873755072385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}