{"id":"W2092512352","doi":"10.1210/me.2009-0254","title":"Physiological Genomics Identifies Estrogen-Related Receptor α as a Regulator of Renal Sodium and Potassium Homeostasis and the Renin-Angiotensin Pathway","year":2009,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute; McGill University Health Centre","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Homeostasis; Endocrinology; Biology; Internal medicine; Renin–angiotensin system; Angiotensin II; Kidney; Receptor; Energy homeostasis; Regulator; Glucose homeostasis; Estrogen-related receptor alpha; Estrogen receptor; Blood pressure; Medicine; Diabetes mellitus; Gene; Biochemistry; Insulin resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001083983,0.0001982737,0.0002945853,0.00005722717,0.00009298183,0.00001622347,0.0001328875,0.0002087419,0.00001235172],"category_scores_gemma":[0.00004701431,0.0001495959,0.0001333378,0.00008067834,0.0005369121,0.000004796669,0.00007131577,0.0001198719,0.000002844626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007672386,"about_ca_system_score_gemma":0.00003769302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001543872,"about_ca_topic_score_gemma":0.000002934713,"domain_scores_codex":[0.9987628,0.000130845,0.0003112737,0.0003944957,0.0001043729,0.0002961567],"domain_scores_gemma":[0.9993938,0.00001191907,0.0001431285,0.0003033874,0.00008363304,0.00006408152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004475976,0.00003268063,0.00006256461,0.000004496286,0.0001040118,0.00002031323,0.00008868473,0.00003196417,0.9836062,0.01148283,0.0001477181,0.003970984],"study_design_scores_gemma":[0.001972737,0.0004894628,0.008784732,0.000008956323,0.00007002377,0.000190738,0.00005917206,0.00007233353,0.9796706,0.003943687,0.004532799,0.0002047242],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901109,0.007153761,0.0004074389,0.001894498,0.00009374196,0.0002221779,0.00001374631,0.00001694007,0.00008675493],"genre_scores_gemma":[0.9981115,0.0008800624,0.000352376,0.000270206,0.00005579447,0.00000949329,0.0001441989,0.00001488884,0.0001614131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008722167,"threshold_uncertainty_score":0.6100345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006046374576326123,"score_gpt":0.2102337500835647,"score_spread":0.2041873755072385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}