{"id":"W2092531009","doi":"10.1074/jbc.m600621200","title":"The Lipoprotein Receptor-related Protein-1 (LRP) Adapter Protein GULP Mediates Trafficking of the LRP Ligand Prosaposin, Leading to Sphingolipid and Free Cholesterol Accumulation in Late Endosomes and Impaired Efflux","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Heart and Stroke Foundation of Canada","keywords":"LRP1; Endosome; ABCA1; Cell biology; LDL receptor; Signal transducing adaptor protein; Biology; Transport protein; Lysosome; Chemistry; Biochemistry; Lipoprotein; Cholesterol; Signal transduction; Intracellular; Transporter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008331939,0.0001979264,0.0004215038,0.0000553666,0.0001290678,0.00006343111,0.0002693144,0.0002550062,0.00001240052],"category_scores_gemma":[0.001405394,0.0001002242,0.0001049768,0.0002645612,0.000275224,0.00009571976,0.0001726401,0.0006191396,7.131591e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009054894,"about_ca_system_score_gemma":0.0000597857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006017713,"about_ca_topic_score_gemma":0.00001706582,"domain_scores_codex":[0.998224,0.0001073481,0.0007152355,0.0002321896,0.0004021214,0.0003190823],"domain_scores_gemma":[0.9989394,0.0001562694,0.0004039037,0.0002126482,0.0001594705,0.0001283375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005139719,0.0001243385,0.02252332,0.0001335723,0.00003683483,0.00001218533,0.0002751581,0.00004177801,0.9720942,0.000003980957,0.00003062948,0.004210024],"study_design_scores_gemma":[0.00321484,0.0004888265,0.1329461,0.001023665,0.00002171452,0.000100853,0.000137843,0.0001371115,0.8611442,0.0003982045,0.0002366306,0.0001499891],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943632,0.001024309,0.000004108478,0.003350972,0.00002428084,0.001138859,0.000004461251,0.0000132455,0.00007649165],"genre_scores_gemma":[0.9992796,0.00004559211,0.000191641,0.00003354005,0.0001662393,0.00003363283,0.00000370991,0.00001536253,0.0002307477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.11095,"threshold_uncertainty_score":0.4087023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02304297614548798,"score_gpt":0.2738280294451214,"score_spread":0.2507850532996334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}