{"id":"W2092531009","doi":"10.1074/jbc.m600621200","title":"The Lipoprotein Receptor-related Protein-1 (LRP) Adapter Protein GULP Mediates Trafficking of the LRP Ligand Prosaposin, Leading to Sphingolipid and Free Cholesterol Accumulation in Late Endosomes and Impaired Efflux","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Heart and Stroke Foundation of Canada","keywords":"LRP1; Endosome; ABCA1; Cell biology; LDL receptor; Signal transducing adaptor protein; Biology; Transport protein; Lysosome; Chemistry; Biochemistry; Lipoprotein; Cholesterol; Signal transduction; Intracellular; Transporter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001465636,0.000770784,0.0004046815,0.0002870051,0.0002126591,0.0004039363,0.0002110492,0.0003837351,0.0007088715],"category_scores_gemma":[0.0001363612,0.0001486569,0.0003285799,0.0001790394,0.0002548941,0.0003275184,0.0005032437,0.0004497571,0.0006541742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002852089,"about_ca_system_score_gemma":0.0001722674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003542257,"about_ca_topic_score_gemma":0.0003447901,"domain_scores_codex":[0.9998404,0.00002982443,0.0000147282,0.00003399411,0.00003949422,0.00004150303],"domain_scores_gemma":[0.9998894,0.00001104393,0.00004832774,0.000011511,0.00001457739,0.00002519629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005643375,0.00000840912,0.0003055228,0.00005295547,0.000007409616,0.000224315,0.000009316654,0.00003382008,0.9978859,0.00009422309,0.00005703192,0.001264784],"study_design_scores_gemma":[0.00001231779,0.0001471266,0.007621523,0.000007287882,0.00002654343,0.001577112,0.00004374932,0.0009849611,0.985927,0.00009964751,0.003544506,0.00000813814],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985327,0.005251051,0.006984389,0.0002237666,0.00004039668,0.0000287295,0.0004093994,0.000233281,0.001502008],"genre_scores_gemma":[0.9902864,0.003302132,0.003014682,0.00009172496,0.00002348892,0.0000485352,0.0006033084,0.00002098571,0.002608651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000770784,"threshold_uncertainty_score":0.00237143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02304297614548798,"score_gpt":0.2738280294451214,"score_spread":0.2507850532996334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}