{"id":"W2092543420","doi":"10.1007/s12079-012-0161-7","title":"CCN3 modulates bone turnover and is a novel regulator of skeletal metastasis","year":2012,"lang":"en","type":"article","venue":"Journal of Cell Communication and Signaling","topic":"Connective Tissue Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Matricellular protein; Osteosarcoma; Wnt signaling pathway; Chondrosarcoma; Cancer research; Biology; Chondrocyte; Bone remodeling; Cell biology; Osteoblast; Cancer; DKK1; Metastasis; Regulator; Signal transduction; Medicine; Cartilage; Pathology; Extracellular matrix; Endocrinology; Anatomy; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001247527,0.0002800731,0.0002243992,0.0002783811,0.0002477829,0.0003295323,0.0001509691,0.00028613,0.0009697788],"category_scores_gemma":[0.0001439626,0.00005758242,0.0001809415,0.0002896539,0.0002160681,0.0001671045,0.0001616329,0.0002515559,0.0001569626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006920373,"about_ca_system_score_gemma":0.0003817937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001768774,"about_ca_topic_score_gemma":0.00280077,"domain_scores_codex":[0.9998939,0.00001530713,0.000005056601,0.00001738957,0.00005004976,0.00001836172],"domain_scores_gemma":[0.9999495,0.00000607789,0.00001674711,0.00000244457,0.00001192494,0.00001346882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004800473,0.00003744309,0.004715419,0.0004572495,0.00005053334,0.001099582,0.00008173729,0.0003622544,0.9513975,0.001969579,0.002097281,0.03725129],"study_design_scores_gemma":[0.0001890652,0.0009896472,0.2092109,0.0001444828,0.0002631423,0.007936055,0.0002824179,0.003944386,0.6237999,0.002965613,0.1501897,0.00008475257],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7713755,0.1987802,0.006344271,0.001372563,0.0003935138,0.0001159103,0.001584562,0.0002822925,0.01975127],"genre_scores_gemma":[0.9653553,0.02805068,0.00150477,0.0002281267,0.00008821653,0.000050361,0.000604977,0.00002055497,0.004097056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001768774,"threshold_uncertainty_score":0.005021095,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02547776396521905,"score_gpt":0.2871588464513766,"score_spread":0.2616810824861576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}