{"id":"W2092576641","doi":"10.1101/gad.177220.111","title":"Splitting the task: Ubp8 and Ubp10 deubiquitinate different cellular pools of H2BK123","year":2011,"lang":"en","type":"article","venue":"Genes & Development","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Simon Fraser University; Child and Family Research Institute","funders":"National Institutes of Health; Michael Smith Health Research BC; Child and Family Research Institute; National Institute of General Medical Sciences; Canadian Institute for Advanced Research; Canadian Institutes of Health Research; Leukemia and Lymphoma Society","keywords":"Biology; H3K4me3; Chromatin; Saccharomyces cerevisiae; Histone; Genome; Transcription (linguistics); Genetics; Computational biology; Yeast; Cell biology; Gene; Promoter; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002940133,0.0001856071,0.0001597339,0.00002856415,0.0001374681,0.00001486088,0.0002229907,0.00009558065,0.00004726093],"category_scores_gemma":[0.00002228622,0.000130815,0.00005176344,0.00004696065,0.0000869036,0.000002498327,0.0003015081,0.00006907292,0.000009145848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009598526,"about_ca_system_score_gemma":0.00007378056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001232266,"about_ca_topic_score_gemma":0.00001733903,"domain_scores_codex":[0.9989207,0.00006430814,0.000296227,0.0002970239,0.0001401378,0.0002816363],"domain_scores_gemma":[0.9994454,0.00001162091,0.0001239042,0.0002758108,0.00006542663,0.00007784949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004343056,0.00005290046,0.007688785,0.00005944618,0.00009803312,0.000003837368,0.001350336,6.151353e-7,0.9368033,0.0002999321,0.00008720935,0.05351218],"study_design_scores_gemma":[0.00022402,0.00008198934,0.02517487,0.00002346023,0.00001651994,0.000009409914,0.0002073004,0.000003756987,0.94231,0.000139837,0.03162823,0.0001806334],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940963,0.002973298,0.0009364624,0.00004378771,0.0001168399,0.0002637938,0.000007811702,0.00001134252,0.001550303],"genre_scores_gemma":[0.9946421,0.0003466839,0.004242853,0.000145149,0.00007787949,0.0000586383,0.00003894874,0.00002069519,0.0004269927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05333155,"threshold_uncertainty_score":0.5334482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02176611138428913,"score_gpt":0.2142767793282365,"score_spread":0.1925106679439474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}