{"id":"W2092576641","doi":"10.1101/gad.177220.111","title":"Splitting the task: Ubp8 and Ubp10 deubiquitinate different cellular pools of H2BK123","year":2011,"lang":"en","type":"article","venue":"Genes & Development","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Simon Fraser University; Child and Family Research Institute","funders":"National Institutes of Health; Michael Smith Health Research BC; Child and Family Research Institute; National Institute of General Medical Sciences; Canadian Institute for Advanced Research; Canadian Institutes of Health Research; Leukemia and Lymphoma Society","keywords":"Biology; H3K4me3; Chromatin; Saccharomyces cerevisiae; Histone; Genome; Transcription (linguistics); Genetics; Computational biology; Yeast; Cell biology; Gene; Promoter; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002320578,0.0003891165,0.0003702893,0.00016332,0.00026916,0.0005746133,0.0004221375,0.0003974716,0.002113617],"category_scores_gemma":[0.0001682546,0.0001955822,0.0003628651,0.0002057604,0.000353926,0.0007167514,0.00061012,0.0006689895,0.0008343279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003427931,"about_ca_system_score_gemma":0.0002228573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005759606,"about_ca_topic_score_gemma":0.0007320553,"domain_scores_codex":[0.9998335,0.00001311273,0.000008769569,0.00006125028,0.00003652736,0.00004686191],"domain_scores_gemma":[0.999895,0.000009333168,0.00002226834,0.00002304671,0.00001374125,0.00003661908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003190736,0.00002665493,0.001043013,0.00005071346,0.00002249261,0.0001180858,0.00003642262,0.0001319354,0.991608,0.0005987876,0.0001133614,0.005931419],"study_design_scores_gemma":[0.00003014083,0.0001029592,0.01013212,0.000006638424,0.00002566547,0.0006783819,0.0001367539,0.001259302,0.9827049,0.0007495192,0.004162993,0.00001068675],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990132,0.002145336,0.005888109,0.0001640864,0.00003958603,0.00001248894,0.000212653,0.00008561296,0.001320179],"genre_scores_gemma":[0.994089,0.0005630951,0.002571495,0.00009469609,0.000007297612,0.00001235277,0.0003658358,0.00003313678,0.002263014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002113617,"threshold_uncertainty_score":0.00707072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02176611138428913,"score_gpt":0.2142767793282365,"score_spread":0.1925106679439474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}