{"id":"W2092590573","doi":"10.1523/jneurosci.3400-07.2007","title":"Puma Is a Dominant Regulator of Oxidative Stress Induced Bax Activation and Neuronal Apoptosis","year":2007,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Krembil Foundation; Heart and Stroke Foundation of Canada","keywords":"Puma; Cell biology; Programmed cell death; Oxidative stress; Apoptosis; Regulator; Biology; Bcl-2-associated X protein; Mitochondrion; Chemistry; Biochemistry; Caspase 3; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002801715,0.00007194173,0.0001033571,0.00008072692,0.00005338576,0.0000144319,0.0001100801,0.0000573371,0.000002111157],"category_scores_gemma":[0.0001050434,0.00005641681,0.00004782983,0.0001209505,0.00007101859,0.00001782948,0.00004833986,0.00006878324,6.653003e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006928608,"about_ca_system_score_gemma":0.00004487021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003025063,"about_ca_topic_score_gemma":9.305713e-7,"domain_scores_codex":[0.9992415,0.0000236425,0.0002512113,0.0001476874,0.0002248555,0.0001110483],"domain_scores_gemma":[0.9993189,0.00001536058,0.000358071,0.00009946316,0.0001396788,0.00006853871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009245746,0.00004255952,0.0003877814,0.00000689203,0.000002732004,8.926358e-7,0.00006065385,0.00001933486,0.9954776,0.00006674423,0.0000279732,0.003814402],"study_design_scores_gemma":[0.0002607059,0.0005889098,0.07209074,0.00002086859,0.00000735769,0.00002663812,0.00004639072,0.00008531767,0.9263627,0.00006056908,0.0003978711,0.00005195053],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907588,0.00002364671,0.008785768,0.0001265352,0.0002131365,0.00005630538,0.000002771294,7.576876e-7,0.00003230384],"genre_scores_gemma":[0.9990355,0.00007792545,0.0005884302,0.0001378229,0.0000873004,2.747632e-7,7.129691e-7,0.000005275733,0.00006672341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07170295,"threshold_uncertainty_score":0.2300611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01666947971548418,"score_gpt":0.2666772236552511,"score_spread":0.2500077439397669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}