{"id":"W2092601184","doi":"10.1021/jm4005972","title":"Synthesis and Structure–Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from <i>Plasmodium falciparum</i>","year":2013,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Health and Medical Research Council; Fundacja na rzecz Nauki Polskiej; Australian Synchrotron","keywords":"Plasmodium falciparum; Chemistry; Enzyme; Arginine; Malaria; Parasite hosting; Biochemistry; Enzyme inhibitor; Amino acid; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002778439,0.0001631979,0.0005716543,0.0000670559,0.00006364637,0.00001081456,0.00009928015,0.0001485869,0.0004897658],"category_scores_gemma":[0.001288987,0.0001040548,0.000153978,0.0001864032,0.0004154148,0.0001023284,0.00005023753,0.0005642785,8.574899e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003981905,"about_ca_system_score_gemma":0.0001553878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001481424,"about_ca_topic_score_gemma":0.00000485581,"domain_scores_codex":[0.9984978,0.00006487751,0.0006046231,0.0001423457,0.0005590837,0.0001313107],"domain_scores_gemma":[0.9979061,0.0005320091,0.0008290207,0.0002194426,0.0002897673,0.0002236046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001717456,0.000132377,0.06188906,0.0002618321,0.0002443589,0.0000166784,0.0002497221,0.000005074397,0.9342963,0.00000349701,0.00122836,0.001501024],"study_design_scores_gemma":[0.001033374,0.0001075241,0.08576229,0.001840019,0.0006085257,0.0003230945,0.0009268652,0.0000970391,0.9089222,0.0002285913,0.00006693726,0.00008355469],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964121,0.0009530186,0.00001529227,0.002048215,0.000032883,0.00007660041,0.00003818826,0.000003947328,0.0004197368],"genre_scores_gemma":[0.9991022,0.0001499526,0.0002910001,0.00009638517,0.0001856925,0.000001480315,0.000002728493,0.00001131287,0.0001592616],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02537409,"threshold_uncertainty_score":0.5362593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01125631013211385,"score_gpt":0.22975540446419,"score_spread":0.2184990943320762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}