{"id":"W2092601184","doi":"10.1021/jm4005972","title":"Synthesis and Structure–Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from <i>Plasmodium falciparum</i>","year":2013,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Health and Medical Research Council; Fundacja na rzecz Nauki Polskiej; Australian Synchrotron","keywords":"Plasmodium falciparum; Chemistry; Enzyme; Arginine; Malaria; Parasite hosting; Biochemistry; Enzyme inhibitor; Amino acid; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002415306,0.0004512222,0.000387514,0.0003163751,0.0001653213,0.0002714999,0.000326611,0.0002507915,0.001227175],"category_scores_gemma":[0.0001793591,0.0001801798,0.0002600607,0.0002414921,0.0001459885,0.0002399958,0.000192548,0.0004303085,0.0003247394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002158288,"about_ca_system_score_gemma":0.0002482739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002322209,"about_ca_topic_score_gemma":0.0006443243,"domain_scores_codex":[0.9999031,0.00002214031,0.00001010104,0.00001658588,0.00002922192,0.00001884754],"domain_scores_gemma":[0.9999224,0.00001512369,0.00002185255,0.000005973766,0.00001087103,0.00002380093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005709528,0.0003770665,0.0002853813,0.0001695616,0.00003024748,0.0002492889,0.00004332065,0.00190298,0.9748526,0.0004574306,0.0003435334,0.02071771],"study_design_scores_gemma":[0.0002737386,0.004608698,0.001160612,0.00001602771,0.00005920819,0.000490625,0.00002286738,0.00151188,0.9835633,0.0001162917,0.008161358,0.0000153691],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9766229,0.007646743,0.008491061,0.0002486263,0.00006792705,0.0003931684,0.0008736196,0.0001603351,0.005495589],"genre_scores_gemma":[0.9770354,0.007017316,0.01135178,0.0001487812,0.00003857711,0.0001265485,0.001183929,0.00002259305,0.003075131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001227175,"threshold_uncertainty_score":0.00410527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01125631013211385,"score_gpt":0.22975540446419,"score_spread":0.2184990943320762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}