{"id":"W2092610623","doi":"10.1016/s0012-1606(03)00097-6","title":"Parp1-deficiency induces differentiation of ES cells into trophoblast derivatives","year":2003,"lang":"en","type":"article","venue":"Developmental Biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Trophoblast; Biology; Embryonic stem cell; Giant cell; Cellular differentiation; Cell biology; Molecular biology; Cell culture; PARP1; Phenotype; Stem cell; Poly ADP ribose polymerase; Genetics; Gene; Placenta; Polymerase; Fetus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006406985,0.0001177955,0.000120133,0.00004737705,0.00004341329,0.000004417715,0.00009471681,0.0001046277,0.00003700961],"category_scores_gemma":[0.00004134004,0.0001067073,0.00003612597,0.00007770905,0.00007656121,0.000001927403,0.0000494411,0.0000389455,0.000006197858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001102701,"about_ca_system_score_gemma":0.00004508767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007592126,"about_ca_topic_score_gemma":0.00001156041,"domain_scores_codex":[0.9993511,0.00003975784,0.0001930077,0.0002137578,0.00004222038,0.000160192],"domain_scores_gemma":[0.9997849,0.00001022083,0.00005515231,0.00008691614,0.00002926765,0.0000335139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008502835,0.00003537063,0.00790188,0.00001288825,0.00001995409,1.967203e-7,0.0002088166,0.00001497933,0.9899256,0.000316818,0.00004381796,0.001511141],"study_design_scores_gemma":[0.0002071098,0.0001232858,0.01409654,0.000004721785,0.000003773738,0.000004084896,0.000282506,0.000002836156,0.9823393,0.0001062655,0.002699327,0.0001302709],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899034,0.0004660906,0.008707961,0.000008597376,0.0001796574,0.0000785528,0.000005693577,0.000006897022,0.0006431414],"genre_scores_gemma":[0.9928991,0.0001283057,0.006788761,0.00002831136,0.00001920623,0.00001151717,0.00006655537,0.000008910291,0.00004938757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007586357,"threshold_uncertainty_score":0.4351399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007237557359265992,"score_gpt":0.2716747697691125,"score_spread":0.2644372124098465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}