{"id":"W2092610623","doi":"10.1016/s0012-1606(03)00097-6","title":"Parp1-deficiency induces differentiation of ES cells into trophoblast derivatives","year":2003,"lang":"en","type":"article","venue":"Developmental Biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Trophoblast; Biology; Embryonic stem cell; Giant cell; Cellular differentiation; Cell biology; Molecular biology; Cell culture; PARP1; Phenotype; Stem cell; Poly ADP ribose polymerase; Genetics; Gene; Placenta; Polymerase; Fetus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003008211,0.0004437725,0.0003842135,0.0003264109,0.0001993891,0.0005255651,0.0003293213,0.0003949357,0.003724013],"category_scores_gemma":[0.0002818765,0.0004404481,0.0003895634,0.0001936026,0.0002605685,0.0002780299,0.0005228995,0.001310178,0.001983368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003368703,"about_ca_system_score_gemma":0.0003019866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006339738,"about_ca_topic_score_gemma":0.0008164832,"domain_scores_codex":[0.9996846,0.00004934668,0.00005808916,0.00008241692,0.00006549266,0.0000600983],"domain_scores_gemma":[0.9995321,0.0001542954,0.00009113686,0.00008266898,0.00002941649,0.0001104224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000116501,0.00001391405,0.0002163917,0.00002849173,0.000008484334,0.000131608,0.00002818617,0.0001159596,0.9978356,0.0001934452,0.0001134444,0.001198127],"study_design_scores_gemma":[0.00001336421,0.00004994681,0.002087798,0.00000537366,0.00001065686,0.0003063391,0.00002415244,0.0004250115,0.9936209,0.0000677763,0.003385419,0.000003187209],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9553345,0.002388894,0.02273188,0.0005250094,0.0002059704,0.0001463107,0.004672181,0.0008534639,0.01314177],"genre_scores_gemma":[0.9657638,0.001323521,0.005973281,0.0001835072,0.00002433738,0.00007801333,0.00338674,0.0002331993,0.02303365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003724013,"threshold_uncertainty_score":0.01245803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007237557359265992,"score_gpt":0.2716747697691125,"score_spread":0.2644372124098465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}