{"id":"W2092652143","doi":"10.1007/s10637-013-0010-4","title":"Sunitinib combined with pemetrexed and carboplatin in patients with advanced solid malignancies—results of a phase I dose-escalation study","year":2013,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Hôpital Notre-Dame","funders":"Pfizer","keywords":"Medicine; Carboplatin; Pemetrexed; Neutropenia; Sunitinib; Rash; Leukopenia; Internal medicine; Adverse effect; Pharmacokinetics; Dosing; Oncology; Gastroenterology; Pharmacology; Toxicity; Chemotherapy; Cancer; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001699145,0.001036208,0.002604212,0.0004089959,0.0003264323,0.0006680682,0.0006898735,0.0007728559,0.001023156],"category_scores_gemma":[0.0008274422,0.000407598,0.001117008,0.0004928572,0.0004570615,0.0006233361,0.0002124216,0.00171739,0.0002717325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000909614,"about_ca_system_score_gemma":0.0008027144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005504846,"about_ca_topic_score_gemma":0.001179789,"domain_scores_codex":[0.999427,0.000261331,0.00004649823,0.0001132905,0.000076607,0.00007540897],"domain_scores_gemma":[0.9994239,0.0001164147,0.0001523621,0.00005651603,0.00003577182,0.0002151473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4123631,0.08516973,0.03344111,0.001856132,0.005782673,0.0006310316,0.0007236814,0.008206732,0.1322764,0.0001702432,0.003296103,0.316083],"study_design_scores_gemma":[0.2346319,0.6634517,0.07812666,0.00006136158,0.001467745,0.00112438,0.00007329669,0.003119863,0.014213,0.0001140216,0.003567048,0.00004900675],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970819,0.002020645,0.0001407466,0.00008205151,0.00002002759,0.0002588264,0.000103863,0.00003476762,0.0002572267],"genre_scores_gemma":[0.9966496,0.001330119,0.0006344639,0.0001649134,0.00006216047,0.0002704537,0.00054887,0.00001185735,0.0003275741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002604212,"threshold_uncertainty_score":0.008986056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01059964471743576,"score_gpt":0.2852261942459808,"score_spread":0.274626549528545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}