{"id":"W2092652143","doi":"10.1007/s10637-013-0010-4","title":"Sunitinib combined with pemetrexed and carboplatin in patients with advanced solid malignancies—results of a phase I dose-escalation study","year":2013,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Hôpital Notre-Dame","funders":"Pfizer","keywords":"Medicine; Carboplatin; Pemetrexed; Neutropenia; Sunitinib; Rash; Leukopenia; Internal medicine; Adverse effect; Pharmacokinetics; Dosing; Oncology; Gastroenterology; Pharmacology; Toxicity; Chemotherapy; Cancer; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005995427,0.0001523836,0.0002555408,0.0001466396,0.00004645451,0.00001633525,0.00003413285,0.0000309685,0.00002976032],"category_scores_gemma":[0.00006909965,0.0001083546,0.00001473851,0.0003550652,0.0001066617,0.0002286063,0.00001310341,0.00007612455,0.000003135051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007070277,"about_ca_system_score_gemma":0.0003596696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008592852,"about_ca_topic_score_gemma":0.0001615261,"domain_scores_codex":[0.998863,0.0000322828,0.0003393723,0.0002381024,0.000385893,0.0001413739],"domain_scores_gemma":[0.9990866,0.00009318389,0.0001874643,0.0001493279,0.0003109535,0.0001724503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003972718,0.003799876,0.9689534,0.00007329456,0.000337346,0.00001124758,0.01075467,0.0005232795,0.001274323,0.0003357894,0.0004177804,0.009546287],"study_design_scores_gemma":[0.05846329,0.004353584,0.9345387,0.0002105255,0.000134587,0.000001326463,0.000988509,0.0003305515,0.0005800067,0.0002574603,0.00001898901,0.0001224556],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99671,0.00001602841,0.00001306442,0.0007334137,0.00002286673,0.001826824,0.00005343456,0.00002200851,0.0006023597],"genre_scores_gemma":[0.9960212,0.000001117697,0.002940289,0.0001484177,0.00001885494,0.0001147343,0.0004672437,0.00001756002,0.0002705719],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05449057,"threshold_uncertainty_score":0.4418574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01059964471743576,"score_gpt":0.2852261942459808,"score_spread":0.274626549528545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}