{"id":"W2092658506","doi":"10.1016/s0021-9290(03)00110-6","title":"Cyclic strain enhances matrix mineralization by adult human mesenchymal stem cells via the extracellular signal-regulated kinase (ERK1/2) signaling pathway","year":2003,"lang":"en","type":"article","venue":"Journal of Biomechanics","topic":"Bone Tissue Engineering Materials","field":"Engineering","cited_by":310,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Dental and Craniofacial Research; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Cell biology; Mesenchymal stem cell; Extracellular matrix; Kinase; Signal transduction; Chemistry; Protein kinase A; p38 mitogen-activated protein kinases; Phosphorylation; Progenitor cell; Stem cell; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001435027,0.0002654603,0.0001500198,0.0002134801,0.0001222094,0.0002111605,0.0001128766,0.0002381454,0.001432212],"category_scores_gemma":[0.0001152452,0.000123682,0.0002309115,0.0001228941,0.0001939728,0.0001340685,0.0001729026,0.0003358099,0.0001659044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002288267,"about_ca_system_score_gemma":0.0002959715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001028735,"about_ca_topic_score_gemma":0.002320674,"domain_scores_codex":[0.9998949,0.00001437751,0.000009109507,0.00001118347,0.00003642264,0.000033978],"domain_scores_gemma":[0.9999136,0.00002316751,0.000020983,0.000009237765,0.00001036179,0.00002270052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002232905,0.00006858145,0.0001565571,0.00002320453,0.000003476926,0.00003660783,0.00001090436,0.00007637736,0.9979458,0.00005778168,0.00004013458,0.001357291],"study_design_scores_gemma":[0.00004556163,0.000535568,0.007659114,0.000005595185,0.00001283618,0.0001182574,0.00003258199,0.0009011332,0.9897051,0.00005570989,0.0009237971,0.000004674605],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975281,0.0006428531,0.0004843739,0.00005575308,0.00002100666,0.00001037342,0.00009022577,0.00002135784,0.001145919],"genre_scores_gemma":[0.9975885,0.0003432523,0.0004540741,0.00002839918,0.000009656917,0.00001416669,0.0001221334,0.000005401821,0.001434482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001432212,"threshold_uncertainty_score":0.0047912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007901289042462945,"score_gpt":0.2064668370735189,"score_spread":0.1985655480310559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}