{"id":"W2092681867","doi":"10.1158/0008-5472.can-06-4249","title":"Inhibition of Cytokine Production and Cytotoxic Activity of Human Antimelanoma Specific CD8+ and CD4+ T Lymphocytes by Adenosine-Protein Kinase A Type I Signaling","year":2007,"lang":"en","type":"article","venue":"Cancer Research","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; University of Pittsburgh; Cancer Institute, University of Pittsburgh; National Cancer Institute; National Institutes of Health; DOD Prostate Cancer Research Program; Cancer Research Institute","keywords":"Adenosine; Cytotoxic T cell; Adenosine A2B receptor; Cytokine; Adenosine A3 receptor; Protein kinase A; Chemistry; Adenosine kinase; CD8; Biology; Cell biology; Adenosine receptor; Molecular biology; Biochemistry; Agonist; Receptor; Kinase; Immune system; Immunology; In vitro; Adenosine deaminase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001533591,0.0003209132,0.0002788343,0.0001115301,0.0001086974,0.0002261528,0.0001360295,0.0002007282,0.0008962755],"category_scores_gemma":[0.0001276294,0.00009163379,0.00022309,0.00008257823,0.0001041738,0.0001092808,0.0001267592,0.0005161965,0.0002437603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001319706,"about_ca_system_score_gemma":0.0001402285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001402336,"about_ca_topic_score_gemma":0.0003431235,"domain_scores_codex":[0.9998102,0.00004987057,0.0000200484,0.00003067425,0.00003582416,0.00005346261],"domain_scores_gemma":[0.9999281,0.00002338398,0.00001640351,0.00001038908,0.000007902408,0.00001380578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003156958,0.0000863317,0.0002619842,0.00005711044,0.000006201465,0.00003645412,0.00001285437,0.0001050164,0.9955226,0.00002847105,0.00002220349,0.003545145],"study_design_scores_gemma":[0.00007288346,0.002178397,0.003925794,0.000008196662,0.00002410714,0.0001936395,0.000021172,0.000660678,0.991271,0.00002238071,0.001618698,0.000003014952],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947936,0.002841297,0.000874683,0.00004298425,0.00002833234,0.00004191455,0.0001028825,0.00002007311,0.001254312],"genre_scores_gemma":[0.9959138,0.001250057,0.001508851,0.00005289353,0.00002998699,0.00007576359,0.0002078499,0.000004747918,0.0009559261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008962755,"threshold_uncertainty_score":0.002998352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03732231700808376,"score_gpt":0.3371893597462716,"score_spread":0.2998670427381878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}