{"id":"W2092681867","doi":"10.1158/0008-5472.can-06-4249","title":"Inhibition of Cytokine Production and Cytotoxic Activity of Human Antimelanoma Specific CD8+ and CD4+ T Lymphocytes by Adenosine-Protein Kinase A Type I Signaling","year":2007,"lang":"en","type":"article","venue":"Cancer Research","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; University of Pittsburgh; Cancer Institute, University of Pittsburgh; National Cancer Institute; National Institutes of Health; DOD Prostate Cancer Research Program; Cancer Research Institute","keywords":"Adenosine; Cytotoxic T cell; Adenosine A2B receptor; Cytokine; Adenosine A3 receptor; Protein kinase A; Chemistry; Adenosine kinase; CD8; Biology; Cell biology; Adenosine receptor; Molecular biology; Biochemistry; Agonist; Receptor; Kinase; Immune system; Immunology; In vitro; Adenosine deaminase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006615,0.00009889466,0.0001473156,0.0001122365,0.0001003176,0.00001223775,0.00005829781,0.0001028309,0.00002541131],"category_scores_gemma":[0.00005811272,0.00009668381,0.00002174678,0.0002378145,0.0002436175,0.00001003545,0.00008699968,0.0001142383,3.855112e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000314898,"about_ca_system_score_gemma":0.00006808505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002166771,"about_ca_topic_score_gemma":0.0000131464,"domain_scores_codex":[0.9990039,0.00007326482,0.0001782777,0.000310264,0.0002134515,0.0002208255],"domain_scores_gemma":[0.9994159,0.00001840306,0.00008456173,0.0001667476,0.000250491,0.00006392001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004346778,0.00005930688,0.001308733,0.0001280947,0.00002441477,0.00000418629,0.00006466924,0.000008066073,0.9960909,0.00002082059,0.0009162472,0.0009398838],"study_design_scores_gemma":[0.000396744,0.0004679133,0.0009135925,0.0001341481,0.000006992739,0.000006654047,0.00007346541,0.00000313946,0.9974933,0.0000464903,0.0003621519,0.00009538217],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891446,0.01030488,0.0001269263,0.00005441924,0.00002322533,0.0002548979,0.00001946826,0.000004419761,0.00006718754],"genre_scores_gemma":[0.998727,0.0006670473,0.00009286727,0.000004612535,0.0002430371,0.0000113884,0.0000278169,0.00001674636,0.0002095489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00963783,"threshold_uncertainty_score":0.3942651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03732231700808376,"score_gpt":0.3371893597462716,"score_spread":0.2998670427381878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}