{"id":"W2092684750","doi":"10.1007/s00249-014-0999-0","title":"Free energy simulations of amylin I26P mutation in a lipid bilayer","year":2014,"lang":"en","type":"article","venue":"European Biophysics Journal","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Amylin; Lipid bilayer; Mutation; Biophysics; Bilayer; Chemistry; Biochemistry; Biology; Gene; Endocrinology; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001709904,0.0001098928,0.0001160031,0.00007115115,0.00004978218,0.00002211357,0.0002111999,0.00004109511,0.00001815301],"category_scores_gemma":[0.0000612363,0.00009571153,0.00008783872,0.0001153638,0.00004277941,0.000007850949,0.00006666301,0.0001132981,0.000003669153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000693118,"about_ca_system_score_gemma":0.00003051433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007399977,"about_ca_topic_score_gemma":0.00001306975,"domain_scores_codex":[0.9991261,0.0001816004,0.0002752532,0.0001513427,0.0001232459,0.0001424795],"domain_scores_gemma":[0.9994131,0.0000117045,0.0001600351,0.0002600512,0.00009484978,0.00006028551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002660298,0.00005676468,0.0006080514,0.000004633837,0.00001222369,0.000005246231,0.00005449088,0.001244944,0.9886373,0.0001967707,0.000173688,0.008979264],"study_design_scores_gemma":[0.001452378,0.0003256086,0.01171584,0.00002886171,0.00003197079,0.00005718723,0.00002426029,0.0003921509,0.9701133,0.0004297144,0.01520826,0.0002204655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936689,0.00001719916,0.003698626,0.00006924054,0.0002618078,0.00003231502,0.00001849171,0.000004650408,0.002228802],"genre_scores_gemma":[0.9978094,0.00002409725,0.00047478,0.0001457991,0.001323809,4.517981e-7,0.00004455046,0.0000246095,0.0001525286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01852402,"threshold_uncertainty_score":0.3903003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008178364651301442,"score_gpt":0.2271784533310515,"score_spread":0.2190000886797501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}