{"id":"W2092718904","doi":"10.1016/j.cardiores.2005.02.018","title":"Modulation of inactivation by mutation N588K in KCNH2: A link to arrhythmogenesis in short QT syndrome","year":2005,"lang":"en","type":"article","venue":"Cardiovascular Research","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Heart, Lung, and Blood Institute; U.S. Public Health Service","keywords":"Short QT syndrome; hERG; Repolarization; Internal medicine; Ventricle; Purkinje fibers; Long QT syndrome; QT interval; Patch clamp; Sudden death; Electrophysiology; Cardiology; Biophysics; Chemistry; Medicine; Potassium channel; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008096301,0.0002826222,0.0001613517,0.0001439337,0.00007193959,0.0001164571,0.0001949356,0.0003490988,0.001282916],"category_scores_gemma":[0.0002385942,0.00006530003,0.0001442867,0.00006417385,0.0002713695,0.0002175898,0.0001961243,0.0002505341,0.0002897962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001519614,"about_ca_system_score_gemma":0.00006486565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001985212,"about_ca_topic_score_gemma":0.0002077169,"domain_scores_codex":[0.9999441,0.000006738267,0.000009396537,0.0000145968,0.00001722749,0.000007827192],"domain_scores_gemma":[0.9999094,0.00001887576,0.00003982777,0.000006675225,0.00000938704,0.00001580271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001230558,0.0000255132,0.003102806,0.00002973713,0.000005201386,0.001212619,0.00002960896,0.00007714908,0.9941413,0.0000561446,0.00002136324,0.001175518],"study_design_scores_gemma":[0.0001501762,0.0009883184,0.1565824,0.00004826249,0.00005418402,0.01905597,0.0001397433,0.004629143,0.8159726,0.000653523,0.001696664,0.00002903876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988996,0.0001690112,0.0005923653,0.00003610612,0.000006207204,0.000005608019,0.00004003708,0.00001174542,0.0002393787],"genre_scores_gemma":[0.9994229,0.00008900238,0.0002782268,0.00002178987,0.000005649418,0.00000590959,0.00004019652,0.000004001841,0.0001323649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001282916,"threshold_uncertainty_score":0.004291832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03352690958704757,"score_gpt":0.3367198298421902,"score_spread":0.3031929202551427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}