{"id":"W2092746828","doi":"10.1186/1742-4690-6-103","title":"Comparative biochemical analysis of HIV-1 subtype B and C integrase enzymes","year":2009,"lang":"en","type":"article","venue":"Retrovirology","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; Canadian Foundation for AIDS Research","keywords":"Integrase; Raltegravir; Elvitegravir; Integrase inhibitor; Enzyme; Virology; Human immunodeficiency virus (HIV); Dolutegravir; Chemistry; Integrases; Biology; Biochemistry; Antiretroviral therapy; Viral load","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002220233,0.0003931678,0.0001609104,0.0005435876,0.0001501064,0.0004513072,0.000202292,0.0002752928,0.001465706],"category_scores_gemma":[0.0004085694,0.000100036,0.0003457481,0.0004331267,0.0001365187,0.0002448353,0.00009066008,0.0003331314,0.0003948689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002456925,"about_ca_system_score_gemma":0.0002434131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001700991,"about_ca_topic_score_gemma":0.001145439,"domain_scores_codex":[0.9998564,0.00002399678,0.00001823254,0.00002834331,0.00004222013,0.00003087401],"domain_scores_gemma":[0.9996861,0.00007246056,0.00006477755,0.00002314389,0.0001016857,0.00005179442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006239616,0.0001206596,0.003402867,0.0001220043,0.00003772484,0.0001021514,0.00004839685,0.0001329754,0.9892666,0.000185457,0.00005095853,0.00590618],"study_design_scores_gemma":[0.00004848568,0.001382792,0.05242686,0.00002657982,0.000112586,0.001884669,0.0001442584,0.001530301,0.9381777,0.0001643911,0.004081903,0.00001941763],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902644,0.004004222,0.002046787,0.00004807338,0.00001781311,0.00003292431,0.0008078714,0.00002402229,0.002753863],"genre_scores_gemma":[0.9850562,0.001997275,0.007476871,0.00005903213,0.00001702965,0.0000293845,0.003541663,0.00001997838,0.001802521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001700991,"threshold_uncertainty_score":0.004903257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01544818591572949,"score_gpt":0.2900465907530761,"score_spread":0.2745984048373466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}