{"id":"W2092761520","doi":"10.1016/j.dci.2009.11.005","title":"Trypanosoma carassii calreticulin binds host complement component C1q and inhibits classical complement pathway-mediated lysis","year":2009,"lang":"en","type":"article","venue":"Developmental & Comparative Immunology","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Directorate for Biological Sciences","keywords":"Calreticulin; Biology; Polyclonal antibodies; Parasite hosting; Complement system; Classical complement pathway; Antibody; Alternative complement pathway; Immune system; Recombinant DNA; Cell biology; Microbiology; Immunology; Biochemistry; Endoplasmic reticulum","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001724391,0.0002699091,0.0003089857,0.0002709089,0.0002412652,0.000333085,0.0002877092,0.0003422861,0.002173267],"category_scores_gemma":[0.0002671754,0.0001397301,0.0001357621,0.0002067879,0.0003051888,0.0001742359,0.0002255365,0.0004934046,0.0005155315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006560305,"about_ca_system_score_gemma":0.0004072873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002782459,"about_ca_topic_score_gemma":0.004234938,"domain_scores_codex":[0.999824,0.00003473668,0.000007818674,0.00001467832,0.00003624646,0.00008257775],"domain_scores_gemma":[0.9998647,0.00004122019,0.00002006698,0.00001956261,0.0000197981,0.00003467415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006611123,0.00006896438,0.0003006191,0.00005429041,0.000009901078,0.0000568362,0.00002484096,0.00005875088,0.9961796,0.0002153014,0.0001861832,0.002183702],"study_design_scores_gemma":[0.00008783671,0.0005848465,0.007786383,0.000006324539,0.00001595007,0.0002382177,0.00003250353,0.0005113364,0.9879178,0.00005505233,0.002758603,0.000005095974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937389,0.002755303,0.0004048752,0.0001243941,0.00003838379,0.00001883415,0.00009674757,0.00003868853,0.002783961],"genre_scores_gemma":[0.9966617,0.0006579987,0.0002960771,0.00005332374,0.00001576202,0.00001016126,0.0002298673,0.000008248249,0.002066788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002782459,"threshold_uncertainty_score":0.007270336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05303383127941154,"score_gpt":0.3292973896575183,"score_spread":0.2762635583781068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}