{"id":"W2092786350","doi":"10.1159/000323880","title":"A Nonsynonymous Polymorphism of IRAK4 Associated with Increased Prevalence of Gram-Positive Infection and Decreased Response to Toll-Like Receptor Ligands","year":2011,"lang":"en","type":"article","venue":"Journal of Innate Immunity","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"National Institutes of Health; Amgen","keywords":"Biology; Single-nucleotide polymorphism; Haplotype; Immunology; Allele; Systemic inflammatory response syndrome; Sepsis; Genetics; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002231474,0.0001816352,0.0004823545,0.0005020241,0.0001322306,0.000007556103,0.0001957314,0.0002288231,0.0001196234],"category_scores_gemma":[0.001420072,0.0001451464,0.0001103838,0.0003554385,0.0002613881,0.0002717031,0.00007066977,0.0004265752,0.000006048855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008371507,"about_ca_system_score_gemma":0.0002764128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008899419,"about_ca_topic_score_gemma":0.00002586224,"domain_scores_codex":[0.9975606,0.001261217,0.0007640282,0.0001097085,0.00009647694,0.0002079543],"domain_scores_gemma":[0.9972699,0.0005482729,0.001152898,0.0002391775,0.0007387699,0.00005100038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03021961,0.0004599115,0.01771836,0.00004164706,0.0004885381,0.000008097611,0.003545285,0.000001496447,0.9465524,0.00001634451,0.00008849258,0.0008598478],"study_design_scores_gemma":[0.0017872,0.002843917,0.4553502,0.0004669625,0.0001248548,0.0001357482,0.0001461595,0.000001029492,0.5389851,0.00001350794,0.0000506007,0.00009463262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986666,0.0006112667,0.0001070329,0.00006803531,0.0001715942,0.0002278481,0.00003307219,0.00001250902,0.0001020548],"genre_scores_gemma":[0.9993945,0.000204133,0.0001317819,0.00004562211,0.000006835973,0.000004703406,0.00001260953,0.00001456449,0.000185218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4376319,"threshold_uncertainty_score":0.5918898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01183223331237446,"score_gpt":0.2202942616806106,"score_spread":0.2084620283682361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}