{"id":"W2092791760","doi":"10.1186/1471-2350-12-10","title":"Testing the thrifty gene hypothesis: the Gly482Ser variant in PPARGC1Ais associated with BMI in Tongans","year":2011,"lang":"en","type":"article","venue":"BMC Medical Genetics","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acadia University","funders":"Max-Planck-Gesellschaft; Acadia University; U.S. Department of Agriculture","keywords":"Human genetics; Genetics; Biology; Evolutionary biology; Statistical hypothesis testing; Computational biology; Gene; Bioinformatics; Statistics; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001011973,0.0002316918,0.0002133263,0.00004283902,0.00009291293,0.00002080199,0.0006413804,0.0003587432,0.00007921935],"category_scores_gemma":[0.002641756,0.0001273188,0.00005139549,0.0004195168,0.0002815192,0.000003394469,0.0001812642,0.0003933844,0.000008439066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003336448,"about_ca_system_score_gemma":0.0005607707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009755954,"about_ca_topic_score_gemma":0.001598361,"domain_scores_codex":[0.9978599,0.0004428961,0.0003801705,0.0003944229,0.0004393928,0.0004831968],"domain_scores_gemma":[0.9988413,0.000315693,0.0001214698,0.0004970105,0.00007817389,0.0001463418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003967351,0.0009442436,0.6881692,0.00003794655,0.0002600692,0.0001460647,0.001724449,0.0004938913,0.2983142,0.00005833476,0.0007533781,0.008701472],"study_design_scores_gemma":[0.002374034,0.0005996982,0.5911265,0.0001994712,0.00006217076,0.0001225046,0.000584697,0.002011972,0.4009053,0.000206263,0.001192714,0.0006146987],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971057,0.0007418719,0.000542757,0.0001544159,0.0001143916,0.0003323102,0.000007951004,0.00001674885,0.0009838808],"genre_scores_gemma":[0.9965479,0.0001829969,0.00223955,0.0006642508,0.0001638541,0.00008934239,0.00001299513,0.00004157491,0.00005752801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.102591,"threshold_uncertainty_score":0.5191908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05581088611394051,"score_gpt":0.2364361658732711,"score_spread":0.1806252797593306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}