{"id":"W2092806983","doi":"10.1016/j.chembiol.2007.09.009","title":"Mechanism-of-Action Determination of GMP Synthase Inhibitors and Target Validation in Candida albicans and Aspergillus fumigatus","year":2007,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Genome Canada","keywords":"Aspergillus fumigatus; Candida albicans; Biology; ATP synthase; Antifungal drug; Biochemistry; Mechanism of action; Enzyme; Microbiology; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002762616,0.00007546514,0.0002050313,0.000037678,0.00001704206,0.000001358954,0.00001915002,0.0001634123,0.00004452832],"category_scores_gemma":[0.000190137,0.00006902185,0.00002225538,0.0000791836,0.0001536373,0.00002936739,0.00001448456,0.00008494558,1.646303e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004701916,"about_ca_system_score_gemma":0.00004022009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001273229,"about_ca_topic_score_gemma":0.0000561957,"domain_scores_codex":[0.999385,0.00001535469,0.0002511188,0.0001799055,0.00005320522,0.000115443],"domain_scores_gemma":[0.9996178,0.00006504539,0.0001039008,0.00009998964,0.00005967548,0.00005365519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001888741,0.00004154428,0.1130098,0.0002160893,0.000005105917,0.000004341531,0.00009529848,1.023638e-7,0.8820198,0.00004283354,0.000002366615,0.004373875],"study_design_scores_gemma":[0.000485085,0.0000999402,0.04336599,0.0000540573,0.00001800745,0.00001373417,0.0003597059,0.00007069251,0.9550241,0.0003738814,0.00007955497,0.00005522914],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978239,0.0002247206,0.001318071,0.0000580262,0.00003559308,0.00009578337,0.00001001179,0.000006696742,0.0004272061],"genre_scores_gemma":[0.999373,0.0001014336,0.0003609443,0.00001571269,0.00003535574,0.000002280701,0.00005299441,0.00000433892,0.00005394977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07300439,"threshold_uncertainty_score":0.2814629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01540254954573374,"score_gpt":0.2980921616497808,"score_spread":0.282689612104047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}