{"id":"W2092806983","doi":"10.1016/j.chembiol.2007.09.009","title":"Mechanism-of-Action Determination of GMP Synthase Inhibitors and Target Validation in Candida albicans and Aspergillus fumigatus","year":2007,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Genome Canada","keywords":"Aspergillus fumigatus; Candida albicans; Biology; ATP synthase; Antifungal drug; Biochemistry; Mechanism of action; Enzyme; Microbiology; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005039983,0.0004463354,0.0005152816,0.0004323866,0.0002571422,0.0003117399,0.0003548064,0.0003335127,0.0006037764],"category_scores_gemma":[0.0004070563,0.0002367041,0.0003630349,0.0002499521,0.000217276,0.0002376362,0.0001459007,0.0005428147,0.0001626162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004886558,"about_ca_system_score_gemma":0.0003970647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002226546,"about_ca_topic_score_gemma":0.002769119,"domain_scores_codex":[0.9997994,0.0000519937,0.00002494652,0.00002818592,0.00005701086,0.00003849588],"domain_scores_gemma":[0.9998659,0.00003539317,0.00002216978,0.00001647861,0.00004424412,0.00001588365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004284939,0.00008557961,0.0002335643,0.00005384811,0.00001067443,0.00008218102,0.00001802576,0.0006352548,0.9939072,0.0001820783,0.00005426749,0.004308909],"study_design_scores_gemma":[0.0000293262,0.0005660587,0.000788704,0.000003166846,0.00001712334,0.0001445102,0.00001040595,0.000768779,0.9970278,0.00003128986,0.0006080869,0.000004724378],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853119,0.005180298,0.006446487,0.0001611094,0.00004343982,0.0001785589,0.0006640796,0.00009827357,0.001915858],"genre_scores_gemma":[0.99113,0.001910471,0.005033521,0.00005326742,0.000008268474,0.00006615331,0.0006382126,0.00001465199,0.001145538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002226546,"threshold_uncertainty_score":0.004427135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01540254954573374,"score_gpt":0.2980921616497808,"score_spread":0.282689612104047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}