{"id":"W2092849088","doi":"10.1128/aac.47.2.670-675.2003","title":"Isoniazid Activation Defects in Recombinant <i>Mycobacterium tuberculosis</i> Catalase-Peroxidase (KatG) Mutants Evident in InhA Inhibitor Production","year":2003,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Manitoba","keywords":"INHA; Isoniazid; Mycobacterium tuberculosis; Chemistry; Mutant; Peroxidase; Microbiology; Biochemistry; Enzyme; Molecular biology; Biology; Tuberculosis; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001518047,0.0003778099,0.0002022141,0.0001307984,0.00008932174,0.0002401215,0.0002565002,0.0002648962,0.0005338508],"category_scores_gemma":[0.0002697167,0.0001347906,0.0002975261,0.0001865811,0.0002320583,0.0001285166,0.0002025336,0.0004067485,0.0002980803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002735255,"about_ca_system_score_gemma":0.0001612515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001174279,"about_ca_topic_score_gemma":0.0008205997,"domain_scores_codex":[0.9997388,0.0000624962,0.00005425096,0.00003698035,0.00007291532,0.0000346339],"domain_scores_gemma":[0.9997997,0.00003730061,0.0000894441,0.00002304327,0.00002099312,0.00002963086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007532361,0.00005059926,0.0004957581,0.0000196167,0.000009428692,0.0001078127,0.00001844356,0.00006314216,0.9984881,0.00005694266,0.00002088534,0.0005940387],"study_design_scores_gemma":[0.00001904121,0.0002824338,0.007099407,0.000006788156,0.00002860656,0.0009971324,0.00006497421,0.0008337537,0.9897753,0.0000392179,0.0008467214,0.000006699884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984096,0.0001511191,0.0008988016,0.00004842559,0.0000115147,0.00001538527,0.0001906387,0.00002978414,0.0002447731],"genre_scores_gemma":[0.9982192,0.0001024329,0.0008837344,0.00002274227,0.000003530623,0.000009391123,0.0004048519,0.0000181154,0.0003358746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001174279,"threshold_uncertainty_score":0.002334893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01789011470285632,"score_gpt":0.2865487873613956,"score_spread":0.2686586726585393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}