{"id":"W2092849088","doi":"10.1128/aac.47.2.670-675.2003","title":"Isoniazid Activation Defects in Recombinant <i>Mycobacterium tuberculosis</i> Catalase-Peroxidase (KatG) Mutants Evident in InhA Inhibitor Production","year":2003,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Manitoba","keywords":"INHA; Isoniazid; Mycobacterium tuberculosis; Chemistry; Mutant; Peroxidase; Microbiology; Biochemistry; Enzyme; Molecular biology; Biology; Tuberculosis; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005880199,0.0002568196,0.0004798018,0.0002804072,0.0000741375,0.00003197454,0.00006221363,0.0001961219,0.00008202032],"category_scores_gemma":[0.0003039922,0.0002220992,0.00008208902,0.0004167457,0.00008466572,0.0002389923,0.00002404442,0.0003451747,0.0000245559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000213802,"about_ca_system_score_gemma":0.0000906303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004956186,"about_ca_topic_score_gemma":0.0002233804,"domain_scores_codex":[0.9980089,0.0002262444,0.0004764561,0.0005718329,0.0001631973,0.0005533756],"domain_scores_gemma":[0.9993691,0.00005134115,0.00009681287,0.0002626841,0.00006182907,0.0001582398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007044458,0.00108902,0.4780782,0.0002176868,0.00005355941,0.00005568824,0.0005878792,0.00000659316,0.4949119,0.00001697089,0.01916423,0.005113868],"study_design_scores_gemma":[0.004884457,0.0003703618,0.5665556,0.0007414506,0.00002050213,0.0001714604,0.00009618486,0.00004350281,0.4093442,0.00005625384,0.01738125,0.0003348059],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884891,0.00007160864,0.00000540847,0.01016389,0.0003230872,0.0007873825,0.000004650692,0.00002856429,0.0001262918],"genre_scores_gemma":[0.9893443,0.003563662,0.0001251301,0.006503901,0.0001179248,0.00003722414,0.00005436728,0.0000366348,0.0002168722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08847741,"threshold_uncertainty_score":0.9056943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01789011470285632,"score_gpt":0.2865487873613956,"score_spread":0.2686586726585393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}