{"id":"W2092850906","doi":"10.1074/jbc.m114.568535","title":"Suppression of the DHX9 Helicase Induces Premature Senescence in Human Diploid Fibroblasts in a p53-dependent Manner","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Helicase; Biology; Cell biology; DNA repair; DNA replication; Senescence; RNA Helicase A; DNA re-replication; DNA damage; Telomere; Control of chromosome duplication; Premature aging; DNA; Cell cycle; Genetics; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001284427,0.0002566262,0.0001937221,0.0002046462,0.000108088,0.0002238127,0.0001234,0.0001623268,0.001424128],"category_scores_gemma":[0.0001038288,0.0001189773,0.0001860893,0.0001520533,0.0001298655,0.00007510762,0.0001231983,0.0003339005,0.0003709026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002022472,"about_ca_system_score_gemma":0.000238958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009953086,"about_ca_topic_score_gemma":0.001064996,"domain_scores_codex":[0.9998901,0.00001572276,0.00001849025,0.0000266257,0.00002750555,0.00002150961],"domain_scores_gemma":[0.999895,0.00002252287,0.00001750216,0.00001926968,0.000009474034,0.00003622774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008646902,0.00001666031,0.0001040308,0.00001097241,0.000003728285,0.00006337078,0.000008412459,0.00002946973,0.9990059,0.00004429291,0.00003149275,0.0005953059],"study_design_scores_gemma":[0.00002650412,0.0003352526,0.003945,0.000003643874,0.00001059715,0.0002276391,0.00002245466,0.0008794346,0.9924429,0.00005174302,0.002051086,0.000003621004],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942381,0.001268012,0.002280921,0.00009105699,0.00004895769,0.00003414637,0.0008952401,0.0001046575,0.001038811],"genre_scores_gemma":[0.9943473,0.0005290285,0.001112292,0.00004208416,0.000007383439,0.0000331849,0.0006542859,0.00001284848,0.003261775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001424128,"threshold_uncertainty_score":0.004764199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01947326507675321,"score_gpt":0.2733407411255739,"score_spread":0.2538674760488207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}