{"id":"W2092853938","doi":"10.1111/j.0022-202x.2004.23539.x","title":"Agonists of Proteinase-Activated Receptor-2 Stimulate Upregulation of Intercellular Cell Adhesion Molecule-1 in Primary Human Keratinocytes via Activation of NF-kappa B","year":2005,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":129,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Institutes of Health; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft","keywords":"Downregulation and upregulation; Receptor; Cell biology; Cell adhesion molecule; Signal transduction; Inflammation; Chemistry; NFKB1; Intercellular Adhesion Molecule-1; NF-κB; Biology; Immunology; Biochemistry; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002151149,0.0004118455,0.0003363627,0.0003479357,0.0003041296,0.0005054424,0.0001436193,0.0003568293,0.003759834],"category_scores_gemma":[0.0002139294,0.0002576647,0.0006024422,0.0002269559,0.0001776543,0.0003028446,0.0002351701,0.0008823659,0.0008810138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002922414,"about_ca_system_score_gemma":0.0002626617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008131783,"about_ca_topic_score_gemma":0.001563988,"domain_scores_codex":[0.9996296,0.00008497559,0.00003345243,0.00002998631,0.00007727374,0.0001446926],"domain_scores_gemma":[0.9998611,0.0000456079,0.00001804108,0.00002218679,0.00002454849,0.00002845367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006086983,0.0002586853,0.0005973481,0.0001516668,0.00001775155,0.0003832928,0.00009360324,0.00005645985,0.995861,0.00009085056,0.0003040964,0.001576574],"study_design_scores_gemma":[0.0001560114,0.001577083,0.02596619,0.00003449502,0.00007861456,0.001131579,0.000628766,0.0009181889,0.9650081,0.0002202934,0.004262707,0.00001797424],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911159,0.003007749,0.001053533,0.0001875974,0.0001612206,0.00009609613,0.000514325,0.00004581323,0.003817639],"genre_scores_gemma":[0.9929315,0.001733437,0.0007899028,0.000122124,0.00003696144,0.0001076425,0.0004735924,0.000007013283,0.003797895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003759834,"threshold_uncertainty_score":0.01257789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02538810645724934,"score_gpt":0.271213274094939,"score_spread":0.2458251676376897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}