{"id":"W2092857000","doi":"10.1038/ncomms5187","title":"Interferon controls SUMO availability via the Lin28 and let-7 axis to impede virus replication","year":2014,"lang":"en","type":"article","venue":"Nature Communications","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Cancer Research; Institut National Du Cancer; Institut Universitaire de France; Centre National de la Recherche Scientifique; Ligue Contre le Cancer; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche","keywords":"SUMO protein; Biology; Cell biology; Interferon; Ubiquitin; Promyelocytic leukemia protein; Haematopoiesis; Stem cell; IRF1; Genetics; Nuclear protein; Gene expression; Transcription factor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007219943,0.000108475,0.0001028516,0.00002152698,0.0002699458,0.00003951081,0.0007690855,0.000226552,0.000009906503],"category_scores_gemma":[0.0007811898,0.00008314988,0.00004836678,0.00008393812,0.0001404859,0.000004098492,0.0004858209,0.0003885709,0.00002302721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001407236,"about_ca_system_score_gemma":0.00002259606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004675276,"about_ca_topic_score_gemma":0.0007722648,"domain_scores_codex":[0.9990422,0.0002804497,0.000179076,0.0002888085,0.00007546602,0.0001339683],"domain_scores_gemma":[0.9965187,0.0001315673,0.00007297763,0.003062113,0.0001417645,0.00007290443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000735157,0.00006805793,0.001564239,0.00000776877,0.00002830963,2.689781e-8,0.0001895589,0.000001793762,0.9653639,0.003038171,0.004251253,0.02541336],"study_design_scores_gemma":[0.0002643039,0.000248155,0.008607017,0.0000101244,0.00001971166,0.000007272942,0.00003829992,0.0003413304,0.2101961,0.0004589932,0.7796475,0.0001612331],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9452925,0.009937528,0.007163374,0.02662889,0.0001707872,0.001442558,0.0001067279,0.00007119399,0.009186479],"genre_scores_gemma":[0.9946356,0.0003526141,0.001771375,0.002612302,0.0001136618,0.0001651085,0.000157635,0.00001298963,0.0001787036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7753962,"threshold_uncertainty_score":0.3390754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01585608904068776,"score_gpt":0.292398507361972,"score_spread":0.2765424183212842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}