{"id":"W2092857000","doi":"10.1038/ncomms5187","title":"Interferon controls SUMO availability via the Lin28 and let-7 axis to impede virus replication","year":2014,"lang":"en","type":"article","venue":"Nature Communications","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Cancer Research; Institut National Du Cancer; Institut Universitaire de France; Centre National de la Recherche Scientifique; Ligue Contre le Cancer; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche","keywords":"SUMO protein; Biology; Cell biology; Interferon; Ubiquitin; Promyelocytic leukemia protein; Haematopoiesis; Stem cell; IRF1; Genetics; Nuclear protein; Gene expression; Transcription factor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003548106,0.0004043124,0.0002663425,0.0003046028,0.0004021299,0.0008811821,0.000328892,0.0005488,0.003176757],"category_scores_gemma":[0.0003413416,0.000290639,0.0004199899,0.0000994456,0.0003238549,0.0006693549,0.0007862201,0.001170412,0.001119014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008300367,"about_ca_system_score_gemma":0.0003651325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004061007,"about_ca_topic_score_gemma":0.001149394,"domain_scores_codex":[0.9996347,0.00005590099,0.00002238733,0.0000785552,0.0001108069,0.00009758152],"domain_scores_gemma":[0.9997218,0.00003910164,0.00007248844,0.00004153984,0.00005126973,0.00007375957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000166773,0.00001949094,0.0005366014,0.00002201031,0.00001062337,0.00004909016,0.00001621499,0.0001367862,0.9959449,0.0007308619,0.0001957595,0.002170954],"study_design_scores_gemma":[0.00003888439,0.0001146219,0.006158033,0.00001070209,0.0000188293,0.0001329707,0.00007426876,0.004201046,0.9815125,0.0008271223,0.00689999,0.00001090252],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760821,0.003712939,0.009478156,0.0009369176,0.0003058002,0.0000337231,0.0004306786,0.0004041239,0.008615462],"genre_scores_gemma":[0.9913774,0.0006588215,0.002862672,0.0001495418,0.00003490322,0.00002189487,0.0002690785,0.0000766677,0.004549031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003176757,"threshold_uncertainty_score":0.01062727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01585608904068776,"score_gpt":0.292398507361972,"score_spread":0.2765424183212842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}