{"id":"W2092859042","doi":"10.1096/fj.05-4195fje","title":"Amyloid‐β induces disulfide bonding and aggregation of GAPDH in Alzheimer's disease","year":2005,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Association France Alzheimer","keywords":"Glyceraldehyde 3-phosphate dehydrogenase; Chemistry; Cytoplasm; Biochemistry; Amyloid (mycology); Cell biology; Enzyme; Biology; Dehydrogenase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001778548,0.0002300856,0.0001443653,0.0003026544,0.0002335604,0.000231676,0.00006848194,0.0001884043,0.0006751486],"category_scores_gemma":[0.0001283575,0.0001807017,0.000234495,0.0001448501,0.0001907839,0.0001498641,0.0001772158,0.0003103873,0.0001747217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001971525,"about_ca_system_score_gemma":0.0001090963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002592235,"about_ca_topic_score_gemma":0.0003430563,"domain_scores_codex":[0.9999384,0.00001628141,0.000007526936,0.000009798325,0.0000157372,0.00001227379],"domain_scores_gemma":[0.9999193,0.00000935009,0.00002599311,0.000009679793,0.00001575032,0.00001994376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000239465,0.00005777572,0.001341925,0.00003140924,0.00001747614,0.000375375,0.00005063901,0.00003007424,0.9964119,0.0001223933,0.0000845875,0.001237031],"study_design_scores_gemma":[0.00007948231,0.0009325021,0.08403238,0.00001991987,0.00007931724,0.004551714,0.0001917747,0.0007792049,0.9048662,0.0009056072,0.00355037,0.00001157572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973391,0.001424322,0.0005008848,0.00005783539,0.00002706258,0.000006126151,0.00004039748,0.00001428255,0.0005899659],"genre_scores_gemma":[0.9978514,0.0008403491,0.0003398469,0.000038616,0.00001659076,0.0000082016,0.0001388362,0.000004063356,0.0007622551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006751486,"threshold_uncertainty_score":0.002258599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03546201108120397,"score_gpt":0.3159480006614311,"score_spread":0.2804859895802272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}