{"id":"W2092920458","doi":"10.1089/hum.2012.013","title":"Targeted Delivery of Self-Complementary Adeno-Associated Virus Serotype 9 to the Brain, Using Magnetic Resonance Imaging-Guided Focused Ultrasound","year":2012,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":203,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital; University of Toronto; Ontario Brain Institute; Sunnybrook Health Science Centre","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Gene delivery; Magnetic resonance imaging; Striatum; Medicine; Adeno-associated virus; Genetic enhancement; Hippocampus; Ultrasound; Pathology; Neuroscience; Biology; Gene; Internal medicine; Vector (molecular biology); Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001747723,0.0004146312,0.0003355607,0.0002370492,0.000114818,0.0003283835,0.000270802,0.000528598,0.000520033],"category_scores_gemma":[0.0001641324,0.0001472774,0.0002774161,0.0001272239,0.0003966741,0.0003466404,0.0002447975,0.0003613134,0.0002621318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00030539,"about_ca_system_score_gemma":0.0003361938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008275302,"about_ca_topic_score_gemma":0.001498141,"domain_scores_codex":[0.9998747,0.00001828874,0.000008496574,0.00004538272,0.00002882221,0.00002427699],"domain_scores_gemma":[0.9999483,0.00001245288,0.00001893554,0.000005419657,0.000004917521,0.00001005807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000216705,0.00001596935,0.00003538436,0.00002998073,0.000003832573,0.00002784838,0.000006743229,0.0001095387,0.9982786,0.0001169412,0.00002681224,0.001326782],"study_design_scores_gemma":[0.00002252995,0.0005731197,0.0006566017,0.000009926646,0.00003117598,0.0003210639,0.00001343818,0.001482946,0.9948621,0.0001056135,0.001913455,0.000007994294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9354016,0.007564428,0.05361929,0.0002310396,0.0001209246,0.0002299097,0.0002989279,0.000326968,0.002206986],"genre_scores_gemma":[0.9363584,0.006707686,0.05362833,0.0001480608,0.00004436917,0.0001264556,0.0003329497,0.00004030319,0.002613576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008275302,"threshold_uncertainty_score":0.002215743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02823597044438601,"score_gpt":0.2566980997225149,"score_spread":0.2284621292781289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}