{"id":"W2092920458","doi":"10.1089/hum.2012.013","title":"Targeted Delivery of Self-Complementary Adeno-Associated Virus Serotype 9 to the Brain, Using Magnetic Resonance Imaging-Guided Focused Ultrasound","year":2012,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":203,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital; University of Toronto; Ontario Brain Institute; Sunnybrook Health Science Centre","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Gene delivery; Magnetic resonance imaging; Striatum; Medicine; Adeno-associated virus; Genetic enhancement; Hippocampus; Ultrasound; Pathology; Neuroscience; Biology; Gene; Internal medicine; Vector (molecular biology); Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002411045,0.0002195955,0.0002132958,0.00007847483,0.0002550491,0.00003239756,0.0003366945,0.00004834116,0.0004765844],"category_scores_gemma":[0.000008002388,0.0001901137,0.00008186799,0.0003116257,0.00004046157,0.0001094227,0.00002206708,0.0001245157,0.00003773313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001120805,"about_ca_system_score_gemma":0.00002004106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002506548,"about_ca_topic_score_gemma":0.0001079553,"domain_scores_codex":[0.9987845,0.00007234994,0.0003278273,0.0001755685,0.0002010262,0.0004387487],"domain_scores_gemma":[0.9992144,0.0001132196,0.00006148718,0.0004363074,0.00007807304,0.00009653766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001124977,0.0001218835,0.008211012,0.000005869816,0.00006996125,5.104374e-7,0.002993519,0.0004633568,0.9811717,0.00006648255,0.005128035,0.001756439],"study_design_scores_gemma":[0.003589982,0.000256394,0.3815745,0.00006230563,0.0001603482,0.00004991711,0.0004427902,0.002472236,0.4222495,0.0005472399,0.1872554,0.001339391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859572,0.0125478,0.0002075659,0.0001139517,0.000115778,0.0005263257,0.00007242654,0.0002520232,0.0002069259],"genre_scores_gemma":[0.9967719,0.0002561842,0.001711592,0.0007945274,0.0002201406,0.00005715945,0.0000561777,0.00007814414,0.00005411641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5589222,"threshold_uncertainty_score":0.7752613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02823597044438601,"score_gpt":0.2566980997225149,"score_spread":0.2284621292781289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}