{"id":"W2092929477","doi":"10.1155/2014/159459","title":"Unique Pattern of Component Gene Disruption in the NRF2 Inhibitor KEAP1/CUL3/RBX1 E3-Ubiquitin Ligase Complex in Serous Ovarian Cancer","year":2014,"lang":"en","type":"article","venue":"BioMed Research International","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Canadian Institutes of Health Research; University of British Columbia","keywords":"Ubiquitin ligase; Biology; KEAP1; DNA methylation; DNA ligase; Ovarian cancer; Cancer research; Gene; Cell biology; Cancer; Ubiquitin; Molecular biology; Genetics; Gene expression; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001094606,0.0001259826,0.0001475419,0.0002219849,0.00004549923,0.00003398852,0.0005693012,0.0001160913,0.00005605909],"category_scores_gemma":[0.0001397892,0.000104315,0.00006016418,0.0001766327,0.0002395188,0.000006841582,0.0002327621,0.0002284609,0.000006504004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001005773,"about_ca_system_score_gemma":0.00007755989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001227519,"about_ca_topic_score_gemma":0.001218216,"domain_scores_codex":[0.9981446,0.000411666,0.0003486982,0.0003391571,0.0004444954,0.0003113974],"domain_scores_gemma":[0.9992278,0.00006926328,0.00009312508,0.0002716343,0.000270404,0.00006772421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001517238,0.0002535954,0.01197398,0.00002667534,0.00002851666,0.000003818123,0.0002944683,0.00004350165,0.9820686,0.000142867,0.001488043,0.003524222],"study_design_scores_gemma":[0.001542937,0.0001658032,0.128356,0.00007748602,0.00000265525,0.000006548855,0.0003145488,0.001224486,0.8515561,0.0003414849,0.01624527,0.0001666875],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950721,0.00008643668,0.0007675733,0.002988216,0.0001878815,0.0003223055,0.0001912391,0.000003553776,0.0003807437],"genre_scores_gemma":[0.9977097,0.0001348974,0.0002376997,0.0002529683,0.0006863635,0.0001216333,0.0007595352,0.00001467918,0.00008255705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1305125,"threshold_uncertainty_score":0.4253844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06039647094093926,"score_gpt":0.3770964077596567,"score_spread":0.3166999368187174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}