{"id":"W2092946093","doi":"10.1038/ni1132","title":"Disruption of Erk-dependent type I interferon induction breaks the myxoma virus species barrier","year":2004,"lang":"en","type":"article","venue":"Nature Immunology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":182,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Myxoma virus; Interferon; STAT1; Biology; MAPK/ERK pathway; Interferon regulatory factors; Virus; Myxoma; Transcription factor; Innate immune system; Virology; Signal transduction; Cell biology; Immunology; Immune system; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002205208,0.0002199226,0.0001806529,0.0001385315,0.0001730694,0.0003449012,0.0002195534,0.0003484725,0.001179151],"category_scores_gemma":[0.0001952958,0.0001422342,0.0002355583,0.00004535486,0.000278336,0.000322725,0.0002799794,0.001048091,0.0002947002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002572636,"about_ca_system_score_gemma":0.0001405176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000118352,"about_ca_topic_score_gemma":0.0001987142,"domain_scores_codex":[0.9998462,0.00003215252,0.0000124761,0.00002188029,0.00003277317,0.00005447455],"domain_scores_gemma":[0.9998376,0.00003828244,0.00005029023,0.00003110886,0.0000093081,0.00003337195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001268856,0.00001904734,0.00008039682,0.00001649641,0.000003237944,0.00003574736,0.000007874559,0.00003869885,0.998117,0.0006146185,0.00004342211,0.0008966836],"study_design_scores_gemma":[0.00003020384,0.0001214683,0.003972722,0.000008442306,0.00000731749,0.0004102069,0.0000385173,0.0013317,0.9904027,0.0005927741,0.003078077,0.000005769894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923693,0.001002618,0.003909788,0.000545212,0.0000854489,0.00001728783,0.0001195861,0.0000904327,0.001860296],"genre_scores_gemma":[0.9977034,0.0001858465,0.001072622,0.00006540452,0.00001026332,0.00001024701,0.00007146084,0.00001353305,0.0008674538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001179151,"threshold_uncertainty_score":0.003944695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00911822760150331,"score_gpt":0.2510064613649729,"score_spread":0.2418882337634696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}