{"id":"W2092986476","doi":"10.1016/j.virol.2005.08.031","title":"The R362A mutation at the C-terminus of CA inhibits packaging of human immunodeficiency virus type 1 RNA","year":2005,"lang":"en","type":"article","venue":"Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; Canadian Foundation for AIDS Research; amfAR, The Foundation for AIDS Research","keywords":"Biology; Context (archaeology); RNA; Capsid; C-terminus; Mutation; CTD; RNase H; Peptide sequence; Linker; Virology; Molecular biology; N-terminus; Sequence (biology); Viral replication; RNase P; Virus; Genetics; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004385792,0.0005706553,0.0007522018,0.0003567385,0.0004035783,0.0007083201,0.0008767002,0.0008059396,0.00291076],"category_scores_gemma":[0.0006026131,0.0003373673,0.0005927173,0.0003143822,0.000860132,0.0003482817,0.0002863775,0.0009929617,0.001372173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007058911,"about_ca_system_score_gemma":0.0006108152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00260914,"about_ca_topic_score_gemma":0.001980476,"domain_scores_codex":[0.9994633,0.0001126607,0.00007819421,0.00008660015,0.0001371804,0.000122202],"domain_scores_gemma":[0.9993141,0.0002151245,0.0001340077,0.0001167788,0.00004217925,0.0001778114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003576469,0.0001062702,0.0001050282,0.00003589623,0.00001570833,0.0001305249,0.0000163248,0.0001953664,0.997619,0.000264568,0.0001439774,0.001009733],"study_design_scores_gemma":[0.0001285824,0.0004715692,0.001614386,0.00001233666,0.0000235945,0.0007099485,0.0000207705,0.001311448,0.9928778,0.0001231419,0.002687756,0.0000188443],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940094,0.001116021,0.001268529,0.0001804691,0.0001478552,0.00004436539,0.0003272773,0.000143669,0.002762455],"genre_scores_gemma":[0.9959152,0.0003915258,0.001278099,0.00009054981,0.00004324344,0.00002468168,0.0004318741,0.00006994946,0.00175489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00291076,"threshold_uncertainty_score":0.009737492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01415196710897399,"score_gpt":0.2806748493815668,"score_spread":0.2665228822725928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}