{"id":"W2092987106","doi":"10.1128/aac.05166-11","title":"<i>In Vitro</i> Resistance Profile of the Hepatitis C Virus NS3 Protease Inhibitor BI 201335","year":2011,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Hepatitis C virus research","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"NS3; Virology; Genotype; In vitro; Protease; Protease inhibitor (pharmacology); Biology; Replicon; Hepatitis C virus; Virus; Genetics; Enzyme; Gene; Biochemistry; Plasmid; Viral load","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001633429,0.0001525011,0.0002838998,0.0000783711,0.00006853869,0.0000140734,0.0001601883,0.00009700761,0.000614305],"category_scores_gemma":[0.00002431116,0.0001083784,0.00008643229,0.0002552262,0.0002075255,0.00009586087,0.00005951265,0.0001924903,0.00002443812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003626708,"about_ca_system_score_gemma":0.00009832657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00267375,"about_ca_topic_score_gemma":0.0003817173,"domain_scores_codex":[0.9988324,0.00006392456,0.0002991909,0.0002672641,0.0002457523,0.0002914533],"domain_scores_gemma":[0.9993911,0.00001140149,0.0000979668,0.0003293135,0.00007932234,0.00009089133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001378589,0.0006937705,0.1474823,0.0002768528,0.00006149824,0.00005659275,0.001287646,2.870824e-8,0.72913,0.00002846232,0.1136137,0.005990522],"study_design_scores_gemma":[0.001940404,0.00007849804,0.08916084,0.0002022292,0.00001099419,0.000005381157,0.000007963316,0.00001346424,0.85505,0.0000356964,0.05337281,0.000121753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924389,0.00005145789,0.000008027509,0.002418791,0.0001069173,0.001064334,0.00009690693,0.00001522456,0.00379951],"genre_scores_gemma":[0.9865764,0.001759443,0.001076969,0.00605325,0.00009385856,0.00003846698,0.000008220538,0.00003774014,0.004355635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.12592,"threshold_uncertainty_score":0.6726209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02232939372696058,"score_gpt":0.2665233618157306,"score_spread":0.24419396808877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}