{"id":"W2092987106","doi":"10.1128/aac.05166-11","title":"<i>In Vitro</i> Resistance Profile of the Hepatitis C Virus NS3 Protease Inhibitor BI 201335","year":2011,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Hepatitis C virus research","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"NS3; Virology; Genotype; In vitro; Protease; Protease inhibitor (pharmacology); Biology; Replicon; Hepatitis C virus; Virus; Genetics; Enzyme; Gene; Biochemistry; Plasmid; Viral load","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002813739,0.0002887865,0.0003735774,0.0002453732,0.0001519432,0.0002571854,0.0002231905,0.0001981126,0.001312399],"category_scores_gemma":[0.0004569663,0.0001453846,0.0002236013,0.0002739668,0.0001188701,0.0001222333,0.0001122447,0.0003635048,0.0005089137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000261899,"about_ca_system_score_gemma":0.0002156718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003223912,"about_ca_topic_score_gemma":0.002778889,"domain_scores_codex":[0.999674,0.0001260342,0.00004513043,0.00003711875,0.00007395029,0.00004373987],"domain_scores_gemma":[0.9997937,0.00005594503,0.00004291259,0.0000287505,0.0000525082,0.00002609827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006539376,0.0001205926,0.000635455,0.00005009041,0.00001931133,0.00003834545,0.0000293313,0.0004469102,0.9933769,0.00006195572,0.0003715752,0.004195547],"study_design_scores_gemma":[0.00003111636,0.002351495,0.00508803,0.000007866336,0.00004587889,0.0002397698,0.00001981735,0.001269015,0.9891269,0.00002429444,0.001784685,0.00001114426],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926577,0.002012045,0.001115633,0.0001140695,0.00004004821,0.00005240324,0.001492711,0.00008253785,0.002432992],"genre_scores_gemma":[0.9922515,0.0009332091,0.002460202,0.00007820093,0.00001945182,0.00003840625,0.002480236,0.00003915261,0.001699819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003223912,"threshold_uncertainty_score":0.006410301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02232939372696058,"score_gpt":0.2665233618157306,"score_spread":0.24419396808877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}