{"id":"W2093015607","doi":"10.1161/01.cir.0000155252.23933.2d","title":"Sildenafil Prevents Endothelial Dysfunction Induced by Ischemia and Reperfusion via Opening of Adenosine Triphosphate–Sensitive Potassium Channels","year":2005,"lang":"en","type":"article","venue":"Circulation","topic":"Cardiac Ischemia and Reperfusion","field":"Medicine","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Heart and Stroke Foundation of Canada","keywords":"Medicine; Sildenafil; Glibenclamide; Placebo; Ischemia; Vasodilation; Crossover study; Brachial artery; Anesthesia; Potassium channel opener; Endothelial dysfunction; Potassium channel; Endothelium; Internal medicine; Adenosine; Pharmacology; Cardiology; Endocrinology; Blood pressure; Diabetes mellitus; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002475242,0.0001720848,0.0003304179,0.00009950455,0.0001018089,0.00001488335,0.00002887364,0.0002269185,0.0000734853],"category_scores_gemma":[0.00008508084,0.0001570613,0.0001044276,0.000171304,0.00003921686,0.0002145805,0.00004746115,0.0001818134,0.000007998719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001214476,"about_ca_system_score_gemma":0.00004478343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006602459,"about_ca_topic_score_gemma":8.455162e-7,"domain_scores_codex":[0.9987238,0.00004556289,0.0003690552,0.0003484857,0.0003313401,0.0001817412],"domain_scores_gemma":[0.9992943,0.00003596855,0.0002061137,0.0002019969,0.0001511045,0.0001105419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003036949,0.00008323879,0.005922788,0.00005651394,0.00003315594,0.000003078241,0.0004517137,0.00005891907,0.9695144,0.000005297164,0.0003545292,0.02321262],"study_design_scores_gemma":[0.002781051,0.0001027527,0.01420024,0.0002201681,0.0001621384,0.0001090291,0.00007529453,0.003833896,0.9778777,0.0000085035,0.0004723781,0.0001568055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963627,0.00046135,0.001118791,0.0003595701,0.0003241549,0.0005663771,0.000008735761,0.00004611463,0.0007521394],"genre_scores_gemma":[0.9985942,0.00007074317,0.0002168484,0.00009545069,0.0004647568,0.0000126171,0.0001860888,0.00002780405,0.0003315189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02305581,"threshold_uncertainty_score":0.6404775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01046296864363973,"score_gpt":0.2434723255702795,"score_spread":0.2330093569266397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}