{"id":"W2093022487","doi":"10.1016/j.yrtph.2012.11.008","title":"Determination of compound-specific acceptable daily intakes for 11 mutagenic carcinogens used in pharmaceutical synthesis","year":2012,"lang":"en","type":"article","venue":"Regulatory Toxicology and Pharmacology","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Kimberly-Clark (Canada)","funders":"U.S. Environmental Protection Agency","keywords":"Carcinogen; Genotoxicity; Chemistry; Biochemical engineering; Impurity; Human use; Toxicology; Combinatorial chemistry; Organic chemistry; Biotechnology; Biology; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005853106,0.0002016464,0.0003629484,0.0001435043,0.00009846546,0.000006521971,0.0001498104,0.0003405924,0.0002397385],"category_scores_gemma":[0.00002886191,0.0002135383,0.0001145412,0.00009762679,0.0003008928,0.00001449368,0.0001079439,0.0001163612,0.000001869735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005325778,"about_ca_system_score_gemma":0.00007120028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006467099,"about_ca_topic_score_gemma":0.00007205504,"domain_scores_codex":[0.9984483,0.0002546721,0.0003656499,0.0003482185,0.00008540262,0.0004977966],"domain_scores_gemma":[0.9992422,0.0002387433,0.0001306375,0.0001777137,0.00006232423,0.0001483087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003099725,0.0003354152,0.06857445,0.00007844844,0.00006201857,0.000003157862,0.0001538546,0.00002726344,0.9257314,0.0003895851,0.0006511582,0.003683236],"study_design_scores_gemma":[0.001610103,0.0002475597,0.06614099,0.000005237839,0.0001132569,0.00004473853,0.0001518668,0.0004411365,0.9086096,0.00002858265,0.02238311,0.0002237891],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945685,0.002362576,0.001690922,0.000144547,0.0005302793,0.000571484,0.00005814664,0.000009198051,0.00006440688],"genre_scores_gemma":[0.9978602,0.0002354029,0.0009520128,0.0002929334,0.0003063382,0.0002113465,0.00003960612,0.00002418173,0.00007801037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02173195,"threshold_uncertainty_score":0.8707841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03543384863096214,"score_gpt":0.3280396811349223,"score_spread":0.2926058325039602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}