{"id":"W2093023060","doi":"10.5402/2012/369270","title":"Efficient Nonviral Gene Therapy Using Folate-Targeted Chitosan-DNA Nanoparticles <i>In Vitro</i>","year":2012,"lang":"en","type":"article","venue":"ISRN Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bombardier (Canada); Université de Montréal; Hôpital du Sacré-Cœur de Montréal","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China","keywords":"Transfection; Chitosan; In vitro; Immunogenicity; DNA; Molecular biology; Chemistry; Genetic enhancement; Intracellular; Cell culture; Gene delivery; Biophysics; Biochemistry; Cell biology; Gene; Biology; Antigen; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001826625,0.0002121816,0.0001623792,0.00005783836,0.00007638575,0.00002360176,0.0001947325,0.0001282759,0.0000191265],"category_scores_gemma":[0.00001122617,0.0002010014,0.0001018125,0.0001346638,0.00006162676,0.000006800173,0.00009406621,0.0001332996,0.00002778169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001985784,"about_ca_system_score_gemma":0.00004730861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001407544,"about_ca_topic_score_gemma":0.000002545497,"domain_scores_codex":[0.9986407,0.00008407385,0.0002605792,0.0002646419,0.0001470087,0.0006030279],"domain_scores_gemma":[0.9994811,0.000008762543,0.00007319465,0.0002602985,0.00003024661,0.0001463451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002915932,0.0002477009,0.007200255,0.000005731676,0.00004877469,0.00000423317,0.0001665167,0.001246582,0.9875893,0.000002801301,0.00003624804,0.003160284],"study_design_scores_gemma":[0.000990778,0.00008883783,0.0009456078,0.000007093249,0.00001993308,0.00001933841,0.00006666728,0.005028585,0.9905065,0.000004327127,0.002063003,0.0002592794],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939884,0.004828216,0.0002051147,0.00003885371,0.0005560535,0.000191747,0.00002560383,0.00001710849,0.0001488902],"genre_scores_gemma":[0.9974585,0.0005538666,0.0005651228,0.0008735486,0.0004327969,0.00001078481,0.00004257104,0.00003317948,0.00002962416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006254647,"threshold_uncertainty_score":0.8196599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04025222310269455,"score_gpt":0.3172281007544377,"score_spread":0.2769758776517432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}