{"id":"W2093023060","doi":"10.5402/2012/369270","title":"Efficient Nonviral Gene Therapy Using Folate-Targeted Chitosan-DNA Nanoparticles <i>In Vitro</i>","year":2012,"lang":"en","type":"article","venue":"ISRN Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bombardier (Canada); Université de Montréal; Hôpital du Sacré-Cœur de Montréal","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China","keywords":"Transfection; Chitosan; In vitro; Immunogenicity; DNA; Molecular biology; Chemistry; Genetic enhancement; Intracellular; Cell culture; Gene delivery; Biophysics; Biochemistry; Cell biology; Gene; Biology; Antigen; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001989041,0.0004483064,0.0002528401,0.000173888,0.0001351544,0.0003796465,0.0003195187,0.0004285333,0.000719833],"category_scores_gemma":[0.0001767979,0.0001723292,0.0002565476,0.0001178335,0.0003092734,0.0002592477,0.0001931675,0.0002992478,0.0002885938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007374999,"about_ca_system_score_gemma":0.0003933599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002061687,"about_ca_topic_score_gemma":0.002717423,"domain_scores_codex":[0.9998091,0.00003434261,0.00001427828,0.0000509587,0.00005541462,0.00003589214],"domain_scores_gemma":[0.9999213,0.00001975055,0.00002871282,0.000008438472,0.00001235505,0.000009373447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001418385,0.000005986224,0.00001699623,0.00003239543,0.000001627703,0.00002133222,0.000008234575,0.00005379166,0.999122,0.00007313043,0.00001403858,0.0006362037],"study_design_scores_gemma":[0.000003277112,0.00004492048,0.0001234704,0.000001647512,0.000003618104,0.00004205666,0.000003008667,0.000251851,0.9989303,0.000009632041,0.0005846685,0.00000156978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9547908,0.007485509,0.03263743,0.0002005822,0.00009007763,0.0001661493,0.0003346407,0.0002402482,0.004054615],"genre_scores_gemma":[0.9781502,0.00175203,0.01378087,0.00005423868,0.00001021767,0.00005682843,0.0002828881,0.00004294719,0.005869779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002061687,"threshold_uncertainty_score":0.005351007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04025222310269455,"score_gpt":0.3172281007544377,"score_spread":0.2769758776517432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}