{"id":"W2093087608","doi":"10.1016/j.cell.2005.02.019","title":"The C2 Domain of PKCδ Is a Phosphotyrosine Binding Domain","year":2005,"lang":"en","type":"article","venue":"Cell","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":255,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Institute of Dental and Craniofacial Research; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Cell biology; Domain (mathematical analysis); Phosphotyrosine-binding domain; Binding domain; Plasma protein binding; Protein kinase C; SH2 domain; Signal transduction; Computational biology; Molecular biology; Genetics; Binding site; Proto-oncogene tyrosine-protein kinase Src","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002154287,0.00008617954,0.0000763616,0.00001727364,0.0001108347,0.0000152328,0.0001268439,0.00007463805,0.00006089464],"category_scores_gemma":[0.00000996117,0.00006519907,0.00007728426,0.00007067159,0.00007063204,0.000001863273,0.0000531847,0.00004599186,0.00002298173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001012043,"about_ca_system_score_gemma":0.00003214477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004138663,"about_ca_topic_score_gemma":0.000005815851,"domain_scores_codex":[0.9993932,0.00002910509,0.0001640665,0.0001545496,0.00009814372,0.0001608859],"domain_scores_gemma":[0.9995781,0.000009269065,0.00008542973,0.0002477352,0.00003520969,0.00004429432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003435326,0.00002514012,0.00005422133,0.000008722539,0.000009272506,6.656667e-7,0.00007265614,0.00002123068,0.9952669,0.0002249591,0.002505306,0.001776555],"study_design_scores_gemma":[0.0003096144,0.00003182163,0.00003666139,0.000007152052,0.00000341821,0.000001996084,0.00005304987,0.00003000488,0.7214702,0.0001707776,0.2778223,0.00006308647],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894097,0.003868811,0.001839321,0.0005993821,0.00005473753,0.0001399115,0.0000127431,0.000007905108,0.004067514],"genre_scores_gemma":[0.9940286,0.0001419852,0.00309856,0.000251805,0.0001554425,0.000009048813,0.0000231735,0.00001327576,0.002278115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.275317,"threshold_uncertainty_score":0.2658741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006328742367526076,"score_gpt":0.2228298122045222,"score_spread":0.2165010698369961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}