{"id":"W2093087608","doi":"10.1016/j.cell.2005.02.019","title":"The C2 Domain of PKCδ Is a Phosphotyrosine Binding Domain","year":2005,"lang":"en","type":"article","venue":"Cell","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":255,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Institute of Dental and Craniofacial Research; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Cell biology; Domain (mathematical analysis); Phosphotyrosine-binding domain; Binding domain; Plasma protein binding; Protein kinase C; SH2 domain; Signal transduction; Computational biology; Molecular biology; Genetics; Binding site; Proto-oncogene tyrosine-protein kinase Src","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001697576,0.0007925772,0.0004128572,0.0004423604,0.0004817802,0.0005183583,0.0005559251,0.0005254178,0.004248035],"category_scores_gemma":[0.0001982816,0.0002606788,0.0004414458,0.000431705,0.0002961115,0.0004615205,0.0004016112,0.0008265868,0.003899739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009819692,"about_ca_system_score_gemma":0.0005346477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001807742,"about_ca_topic_score_gemma":0.001107055,"domain_scores_codex":[0.9998678,0.000007700129,0.000009845553,0.00004139807,0.00003532818,0.00003796604],"domain_scores_gemma":[0.9997906,0.00002147609,0.00005005857,0.00003381375,0.00003545841,0.00006854683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005886086,0.00005636135,0.001042939,0.0001082621,0.0000129098,0.0003740407,0.00001758919,0.0002067316,0.9893765,0.0007392691,0.0005496402,0.006927163],"study_design_scores_gemma":[0.00004887589,0.0001181477,0.01014183,0.00001335209,0.0000185007,0.002300583,0.00003344426,0.001248958,0.9702905,0.0002494369,0.01551493,0.00002126754],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9527724,0.004716259,0.02867123,0.0004428417,0.0003767028,0.0001581089,0.00382166,0.0005314058,0.008509343],"genre_scores_gemma":[0.9703686,0.00126276,0.01032071,0.0001964888,0.00005675643,0.00006962703,0.004039804,0.00004784789,0.01363751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004248035,"threshold_uncertainty_score":0.01421106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006328742367526076,"score_gpt":0.2228298122045222,"score_spread":0.2165010698369961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}