{"id":"W2093120223","doi":"10.3791/3234","title":"Development of a Unilaterally-lesioned 6-OHDA Mouse Model of Parkinson's Disease","year":2012,"lang":"en","type":"article","venue":"Journal of Visualized Experiments","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Connaught Fund; Krembil Foundation; University of Toronto; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Medial forebrain bundle; Direct pathway of movement; Basal ganglia; Neuroscience; Indirect pathway of movement; Striatum; Parkinson's disease; Nigrostriatal pathway; Parkinsonism; Dopamine; Biology; Oxidopamine; Dopaminergic; Disease; Medicine; Substantia nigra; Pathology; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001136633,0.001401588,0.001093009,0.002150424,0.0008290929,0.00114146,0.002256991,0.002677003,0.00510774],"category_scores_gemma":[0.0004053094,0.0009295209,0.0009140522,0.0005938559,0.0009915914,0.001263969,0.0008000283,0.004389581,0.002850937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009719784,"about_ca_system_score_gemma":0.0009042438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001456748,"about_ca_topic_score_gemma":0.002770958,"domain_scores_codex":[0.9988727,0.000104212,0.0001763193,0.0003240479,0.0003877917,0.0001348801],"domain_scores_gemma":[0.999373,0.00005726854,0.0001501911,0.0000717179,0.0001152252,0.0002325354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002355683,0.0006362863,0.0004483755,0.0002155663,0.00003954337,0.0003761547,0.0001294454,0.0002656078,0.988335,0.002067958,0.00108322,0.006167295],"study_design_scores_gemma":[0.0006527416,0.004864272,0.009503469,0.0005044376,0.0003756888,0.004137653,0.0002980184,0.006226155,0.8801439,0.001623702,0.09154408,0.0001257832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.7246425,0.02385918,0.1802438,0.004978566,0.002830069,0.006200007,0.02278824,0.006407269,0.02805029],"genre_scores_gemma":[0.7038403,0.026558,0.1702313,0.00218424,0.0004459378,0.007743164,0.0178369,0.0008532038,0.070307],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.00510774,"threshold_uncertainty_score":0.01708704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05515619224674109,"score_gpt":0.3959538763928528,"score_spread":0.3407976841461118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}