{"id":"W2093141434","doi":"10.1016/s0165-5728(00)00435-5","title":"Expression and function of the costimulatory molecules B7-1 (CD80) and B7-2 (CD86) in an in vitro model of the human blood–brain barrier","year":2001,"lang":"en","type":"article","venue":"Journal of Neuroimmunology","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver General Hospital; University of British Columbia","funders":"","keywords":"CD86; CD80; Biology; T cell; Cell biology; Immunocytochemistry; Molecular biology; In vitro; Monoclonal antibody; Downregulation and upregulation; Cytokine; Immunology; Antibody; CD40; Cytotoxic T cell; Biochemistry; Endocrinology; Gene; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002651956,0.0002219162,0.000262819,0.0002508103,0.0002778598,0.000547473,0.0002312276,0.0003938124,0.0008206962],"category_scores_gemma":[0.0003402968,0.0002578798,0.0002381663,0.0002052674,0.0002576527,0.0004103233,0.0001321281,0.0006765276,0.0003692896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005193999,"about_ca_system_score_gemma":0.0002229533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002552562,"about_ca_topic_score_gemma":0.001877926,"domain_scores_codex":[0.9998115,0.00006399011,0.00001327554,0.00002508213,0.00003873387,0.00004753115],"domain_scores_gemma":[0.9998552,0.00004509545,0.00001948945,0.00002439017,0.00002715772,0.00002866436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003443601,0.00006770313,0.0001443419,0.00002758008,0.000007309456,0.00007180178,0.00006869026,0.00011223,0.9982468,0.0002776178,0.00005031682,0.00058133],"study_design_scores_gemma":[0.00004614851,0.0007864495,0.005986807,0.00001090649,0.00006257532,0.0005943315,0.0001590067,0.002695269,0.9871746,0.0002021055,0.002271573,0.00001012521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955863,0.002165007,0.00103217,0.00005082318,0.00001529859,0.0000113134,0.0001363364,0.000009776904,0.0009928739],"genre_scores_gemma":[0.995522,0.001393278,0.0009176335,0.00002778213,0.000009692907,0.00002098798,0.0004297842,0.000009600862,0.001669147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002552562,"threshold_uncertainty_score":0.005075395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03232885668695422,"score_gpt":0.2634977744810571,"score_spread":0.2311689177941029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}