{"id":"W2093148342","doi":"10.1038/ng2072","title":"Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis","year":2007,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":239,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Nephronophthisis; Positional cloning; Biology; Cancer research; Phenotype; Fibrosis; Gene; Mutant; Mutation; Kidney; Genetics; Pathology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002540944,0.0009722511,0.000506849,0.001316231,0.0003062063,0.0004017703,0.0003681103,0.0008269764,0.003151523],"category_scores_gemma":[0.0002760566,0.0005415012,0.0005391371,0.0003983883,0.001208703,0.0002465465,0.0005961484,0.001112523,0.000410066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003228459,"about_ca_system_score_gemma":0.0003783658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00138934,"about_ca_topic_score_gemma":0.00193318,"domain_scores_codex":[0.9996789,0.00005401571,0.00003559124,0.00009045584,0.00009407309,0.00004700302],"domain_scores_gemma":[0.9996974,0.00004412745,0.0001227289,0.00002966343,0.00001372597,0.00009229354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00113757,0.00005140218,0.002024501,0.00006519961,0.00009868921,0.002486965,0.00006612582,0.000344541,0.9894868,0.0005841196,0.0004656477,0.003188485],"study_design_scores_gemma":[0.0006936035,0.0009287621,0.07776374,0.00004777979,0.0004553376,0.03826665,0.000333064,0.00496466,0.8660117,0.001715692,0.008745339,0.00007365307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920663,0.0007914997,0.003822571,0.0004369325,0.00006414564,0.00003072463,0.001146298,0.0003638072,0.001277851],"genre_scores_gemma":[0.9945351,0.0004509758,0.001986844,0.0001306463,0.0000236348,0.00004132362,0.0004721248,0.00009878857,0.002260515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003151523,"threshold_uncertainty_score":0.01054293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003418472589479238,"score_gpt":0.2356430107420702,"score_spread":0.2322245381525909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}