{"id":"W2093148342","doi":"10.1038/ng2072","title":"Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis","year":2007,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":239,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Nephronophthisis; Positional cloning; Biology; Cancer research; Phenotype; Fibrosis; Gene; Mutant; Mutation; Kidney; Genetics; Pathology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001460486,0.0001765182,0.000182061,0.00006755574,0.00004214615,0.00001443155,0.0001206084,0.0004123845,0.000008182147],"category_scores_gemma":[0.00008538589,0.000177639,0.00004081542,0.0001116457,0.000167509,0.000002423373,0.0001085367,0.0001362298,4.362862e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000084032,"about_ca_system_score_gemma":0.0000475044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007142597,"about_ca_topic_score_gemma":0.00008254855,"domain_scores_codex":[0.9990087,0.0000325419,0.0002350534,0.0003461217,0.0001322966,0.0002452559],"domain_scores_gemma":[0.9994431,0.00002731784,0.00007493098,0.0002175148,0.00007146241,0.0001656479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001209563,0.00007607187,0.1264703,0.00007066642,0.0000368211,0.000001720966,0.00007098302,0.000002991445,0.8696688,0.000004914484,0.002843444,0.0006322495],"study_design_scores_gemma":[0.0007422342,0.0002076687,0.1701905,0.00002259769,0.00005303865,0.000004695228,0.0001411432,0.000004786537,0.8205566,0.00004952481,0.007816046,0.0002111339],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9729575,0.02639605,0.00007370195,0.00005479242,0.00005469676,0.000140968,0.000139931,0.000005061048,0.0001772869],"genre_scores_gemma":[0.9953728,0.002240263,0.001715697,0.000404914,0.0000770787,0.000004455245,0.0001028521,0.0000209315,0.00006100683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04911221,"threshold_uncertainty_score":0.7243909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003418472589479238,"score_gpt":0.2356430107420702,"score_spread":0.2322245381525909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}