{"id":"W2093148632","doi":"10.1002/biot.201300287","title":"Modeling of cell culture damage and recovery leads to increased antibody and biomass productivity in CHO cell cultures","year":2014,"lang":"en","type":"article","venue":"Biotechnology Journal","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chinese hamster ovary cell; Intracellular; Cell culture; Monoclonal antibody; Cell biology; Extracellular; Cell growth; Productivity; Cell; Yield (engineering); Biology; Chemistry; Antibody; Biochemistry; Immunology; Genetics; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000234205,0.0001465801,0.0001838296,0.0001454101,0.0001027061,0.00002649221,0.0001282526,0.0003749481,0.000002817832],"category_scores_gemma":[0.000116634,0.0001193845,0.00004584019,0.000118301,0.00009698604,0.000009974518,0.0001604178,0.0002326912,6.814137e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009005974,"about_ca_system_score_gemma":0.00003010745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004383129,"about_ca_topic_score_gemma":0.00003639608,"domain_scores_codex":[0.9991269,0.0000821876,0.000206271,0.0003117847,0.00007061171,0.0002022367],"domain_scores_gemma":[0.9995307,0.000004835501,0.00009595571,0.0002090982,0.00005924653,0.0001001217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009465615,0.00009550749,0.008589721,0.00004162055,0.000008731547,0.000002956788,0.00003333242,0.0003547182,0.9896803,0.0000113477,0.0004723297,0.0006147148],"study_design_scores_gemma":[0.0007495807,0.0007072516,0.003093873,0.00004121914,0.00001534231,0.00007470621,0.00007302986,0.0006690462,0.99208,0.0002895007,0.002019973,0.0001865293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950691,0.001436023,0.002786693,0.000288367,0.00009762139,0.0001428574,0.00001095798,0.00001124269,0.0001570977],"genre_scores_gemma":[0.9978148,0.000820248,0.001067685,0.00009775289,0.0001170911,0.000005257935,0.00001005263,0.00001196135,0.00005514327],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005495848,"threshold_uncertainty_score":0.4868358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004818532401756979,"score_gpt":0.2469878673797792,"score_spread":0.2421693349780222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}