{"id":"W2093202483","doi":"10.1056/nejmc0907093","title":"FOXP3 Forkhead Domain Mutation and Regulatory T Cells in the IPEX Syndrome","year":2009,"lang":"en","type":"letter","venue":"New England Journal of Medicine","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Forkhead Transcription Factors; Medicine; FOXP3; Mutation; Regulatory T cell; Genetics; Immunology; Regulation of gene expression; Gene; Biology; T cell; Immune system; IL-2 receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001342705,0.001467345,0.002078311,0.0008488913,0.001708831,0.001205175,0.002087418,0.01809738,0.004215392],"category_scores_gemma":[0.007716478,0.0006975001,0.0008771518,0.0006303774,0.001975292,0.001998777,0.0007431825,0.009979659,0.001868308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00199349,"about_ca_system_score_gemma":0.0007127007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001274764,"about_ca_topic_score_gemma":0.0014311,"domain_scores_codex":[0.998922,0.0003336873,0.0001151731,0.0002045136,0.0001929288,0.0002318283],"domain_scores_gemma":[0.9966804,0.002234503,0.0001874954,0.000111868,0.0003024016,0.0004834285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0005140238,0.0001831795,0.005009365,0.0001790703,0.00005097549,0.9081128,0.0002645412,0.0003252272,0.00129143,0.001757407,0.07336381,0.008948116],"study_design_scores_gemma":[0.0006301757,0.0006121869,0.01277404,0.0004493426,0.0001924743,0.9053116,0.0005537991,0.00708828,0.001650508,0.007463305,0.06314258,0.0001317318],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.1658828,0.01669888,0.00348183,0.7152573,0.05735133,0.0002760707,0.00040132,0.0004516798,0.04019876],"genre_scores_gemma":[0.6519167,0.007344117,0.002841656,0.193032,0.1254982,0.0001292243,0.0001959952,0.0001309661,0.01891113],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01809738,"threshold_uncertainty_score":0.01446384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01006786118754564,"score_gpt":0.2278310177552972,"score_spread":0.2177631565677516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}