{"id":"W2093208243","doi":"10.1016/j.humpath.2015.02.010","title":"Loss of ADAM17 is associated with severe multiorgan dysfunction","year":2015,"lang":"en","type":"article","venue":"Human Pathology","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; California Institute of Regenerative Medicine","keywords":"Frameshift mutation; Medicine; Proband; Rash; Exome sequencing; Immunology; Diarrhea; Sepsis; Exome; Mutation; Pathology; Dermatology; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003987884,0.000639507,0.0005936739,0.001128337,0.0002989686,0.0005674114,0.0003232817,0.000519212,0.001958454],"category_scores_gemma":[0.0009047725,0.0002298172,0.0005304916,0.0007167366,0.000576932,0.0002894519,0.0004928025,0.0007903829,0.0003590608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001443036,"about_ca_system_score_gemma":0.0001888164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002141651,"about_ca_topic_score_gemma":0.0002267567,"domain_scores_codex":[0.9996427,0.00009486728,0.00005436989,0.00007884765,0.00007847841,0.00005062387],"domain_scores_gemma":[0.9983994,0.0002073659,0.0008819972,0.000137247,0.00008433238,0.0002895101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003835921,0.0002160303,0.1652106,0.0002814045,0.0007545714,0.04208064,0.0002399145,0.0004847097,0.7674261,0.000789671,0.001197473,0.01748291],"study_design_scores_gemma":[0.00007833029,0.0008391941,0.662561,0.00007778909,0.0005043861,0.1710633,0.0003661775,0.001672886,0.1554037,0.001403545,0.0059759,0.00005381211],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959579,0.001250337,0.00164563,0.0001274062,0.00003518893,0.000007746114,0.0002829472,0.00006494228,0.0006279016],"genre_scores_gemma":[0.9978136,0.0004722772,0.0008441497,0.00003407601,0.00002763104,0.00000473319,0.0003118225,0.00001966725,0.0004721437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001958454,"threshold_uncertainty_score":0.006551683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04198290441621564,"score_gpt":0.2943913293442981,"score_spread":0.2524084249280824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}