{"id":"W2093229695","doi":"10.1038/modpathol.2012.162","title":"PTEN losses exhibit heterogeneity in multifocal prostatic adenocarcinoma and are associated with higher Gleason grade","year":2012,"lang":"en","type":"article","venue":"Modern Pathology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Toronto General Hospital; Robarts Clinical Trials; University Health Network; Queen's University","funders":"Ontario Institute for Cancer Research","keywords":"PTEN; TMPRSS2; Prostate cancer; Erg; Fusion gene; Tensin; Prostate; Biology; Tissue microarray; Cancer research; Prostatectomy; Pathology; Fluorescence in situ hybridization; Malignancy; Cancer; Medicine; Chromosome; Gene; Genetics; PI3K/AKT/mTOR pathway; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003017762,0.0002668748,0.0004243988,0.00267895,0.0003492493,0.000663753,0.000427282,0.0002807386,0.003194774],"category_scores_gemma":[0.001043449,0.000295368,0.0003982057,0.001425447,0.0003834424,0.0004274527,0.0007001708,0.0002785051,0.0004186115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001783963,"about_ca_system_score_gemma":0.0001428427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008551874,"about_ca_topic_score_gemma":0.001088907,"domain_scores_codex":[0.9996448,0.00003829733,0.00002921108,0.00008985186,0.000118084,0.00007977008],"domain_scores_gemma":[0.9990271,0.00017513,0.0004494564,0.00008475107,0.00007715451,0.0001863296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002023096,0.00006587688,0.6724856,0.00009197258,0.0004568489,0.002057846,0.0002927653,0.0004610848,0.3062505,0.0003843634,0.0002459103,0.01518424],"study_design_scores_gemma":[0.0000107624,0.0001053019,0.9892969,0.0000027084,0.00008226288,0.004383079,0.0001278798,0.0003871063,0.004836882,0.0003112074,0.0004451213,0.00001103307],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986155,0.0003936916,0.0003731994,0.00001616081,0.000003228538,0.000003405992,0.0001272265,0.00002405442,0.000443481],"genre_scores_gemma":[0.999402,0.00008640718,0.0001023451,0.000006530064,0.000005189327,0.000003454353,0.0001560583,0.000006971811,0.0002309039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003194774,"threshold_uncertainty_score":0.01068759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0531280467573636,"score_gpt":0.3110570224643642,"score_spread":0.2579289757070006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}