{"id":"W2093229695","doi":"10.1038/modpathol.2012.162","title":"PTEN losses exhibit heterogeneity in multifocal prostatic adenocarcinoma and are associated with higher Gleason grade","year":2012,"lang":"en","type":"article","venue":"Modern Pathology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Toronto General Hospital; Robarts Clinical Trials; University Health Network; Queen's University","funders":"Ontario Institute for Cancer Research","keywords":"PTEN; TMPRSS2; Prostate cancer; Erg; Fusion gene; Tensin; Prostate; Biology; Tissue microarray; Cancer research; Prostatectomy; Pathology; Fluorescence in situ hybridization; Malignancy; Cancer; Medicine; Chromosome; Gene; Genetics; PI3K/AKT/mTOR pathway; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001832245,0.0001753148,0.000356153,0.0001066459,0.00005468902,0.00001110941,0.00004489821,0.0001520869,0.00001889788],"category_scores_gemma":[0.00005036753,0.0001212515,0.00003056988,0.0001237049,0.0002079177,0.00009617242,0.00005347214,0.0002415551,0.00001110655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001525663,"about_ca_system_score_gemma":0.0000447522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004246313,"about_ca_topic_score_gemma":0.0001624612,"domain_scores_codex":[0.998651,0.0001404192,0.0001565272,0.0003102724,0.0001882342,0.0005535467],"domain_scores_gemma":[0.9994418,0.00006620186,0.00006527414,0.0001923754,0.0000500526,0.0001842908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003904112,0.000502884,0.9928687,0.00006873933,0.00005416114,0.0008542759,0.001009189,0.00000268704,0.003024541,0.00000970755,0.00004019972,0.001174544],"study_design_scores_gemma":[0.004112069,0.000427764,0.9916744,0.0001137183,0.0000660923,0.0001890173,0.00007925859,0.000453918,0.00262599,0.00009347778,0.00003221892,0.0001321055],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908205,0.007504709,0.00006024061,0.0008584686,0.0000522053,0.0005337342,0.00002462293,0.0000439473,0.000101625],"genre_scores_gemma":[0.9987506,0.00008103612,0.0001670361,0.0001996409,0.00005273611,0.0001034024,0.0000618066,0.00003080134,0.0005529398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007930154,"threshold_uncertainty_score":0.4944494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0531280467573636,"score_gpt":0.3110570224643642,"score_spread":0.2579289757070006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}