{"id":"W2093239349","doi":"10.1021/ol020047k","title":"Design and Synthesis of Bis 1-Chloromethyl-5-hydroxy-1,2- dihydro-3<i>H</i>-benz[<i>e</i>]indole (<i>s</i><i>eco</i>-CBI)-Pyrrole Polyamide Conjugates","year":2002,"lang":"he","type":"article","venue":"Organic Letters","topic":"Synthesis and pharmacology of benzodiazepine derivatives","field":"Chemistry","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Indole test; Pyrrole; Conjugate; Polyamide; Stereochemistry; Combinatorial chemistry; Medicinal chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009172399,0.001266816,0.001891744,0.0003723103,0.000507985,0.0001828131,0.001104702,0.0006738162,0.02114653],"category_scores_gemma":[0.0006648195,0.001328798,0.0004297832,0.0007486759,0.001321491,0.0004972345,0.000405228,0.0008792638,0.0005241113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001924672,"about_ca_system_score_gemma":0.0001135149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001393323,"about_ca_topic_score_gemma":0.0000048807,"domain_scores_codex":[0.9939262,0.0007224559,0.00156856,0.001535126,0.000750097,0.001497601],"domain_scores_gemma":[0.993185,0.003909075,0.001101351,0.001101456,0.0001330161,0.0005700926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000140484,0.0006609576,0.001154629,0.0006464811,0.001126099,0.000114731,0.001674951,0.00005405489,0.9626495,0.00001859222,0.02914976,0.00260976],"study_design_scores_gemma":[0.002242064,0.0001726145,0.0003612346,0.000479062,0.0009610145,0.0001071549,0.0003896182,0.00210539,0.9865352,0.00004132337,0.005275019,0.001330303],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9719901,0.01091737,0.0004656447,0.01344837,0.0005527107,0.0006232864,0.0002586723,0.0002216581,0.001522202],"genre_scores_gemma":[0.9870911,0.0050645,0.001422613,0.004972337,0.0005122348,0.00008939654,0.00001660918,0.0002897291,0.0005414816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0238857,"threshold_uncertainty_score":0.9989161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01662189248886861,"score_gpt":0.2187111588093459,"score_spread":0.2020892663204773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}