{"id":"W2093239349","doi":"10.1021/ol020047k","title":"Design and Synthesis of Bis 1-Chloromethyl-5-hydroxy-1,2- dihydro-3<i>H</i>-benz[<i>e</i>]indole (<i>s</i><i>eco</i>-CBI)-Pyrrole Polyamide Conjugates","year":2002,"lang":"he","type":"article","venue":"Organic Letters","topic":"Synthesis and pharmacology of benzodiazepine derivatives","field":"Chemistry","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Indole test; Pyrrole; Conjugate; Polyamide; Stereochemistry; Combinatorial chemistry; Medicinal chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001950178,0.0003600639,0.0002178136,0.0001460701,0.0001601738,0.0002553441,0.0003573878,0.0002008905,0.001375628],"category_scores_gemma":[0.0001909266,0.0002010689,0.0001132311,0.000137817,0.0002129927,0.0002144855,0.0001489059,0.0004167572,0.000635488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003903755,"about_ca_system_score_gemma":0.0003452129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003673999,"about_ca_topic_score_gemma":0.0007399268,"domain_scores_codex":[0.9998868,0.00002220571,0.00001310273,0.00002775174,0.00002775605,0.00002242561],"domain_scores_gemma":[0.9998581,0.00001832119,0.0000477465,0.00001592822,0.00002368779,0.00003605222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008681108,0.00002951011,0.00004055296,0.0000398319,0.000002530746,0.00004064441,0.00002094295,0.0002430415,0.9956644,0.0004523878,0.00005972341,0.003319699],"study_design_scores_gemma":[0.00003173974,0.000326179,0.0002018695,0.000002282538,0.000006801039,0.00008648341,0.000005249225,0.0003553153,0.9950973,0.00002838267,0.003854454,0.00000380662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9335308,0.001912962,0.05405602,0.0002809922,0.0001038425,0.0008711796,0.0006221117,0.0003760382,0.008246035],"genre_scores_gemma":[0.936334,0.001604891,0.0517554,0.0001057744,0.00002526061,0.0004708526,0.0005390072,0.00007061283,0.009094185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001375628,"threshold_uncertainty_score":0.004601896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01662189248886861,"score_gpt":0.2187111588093459,"score_spread":0.2020892663204773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}