{"id":"W2093260892","doi":"10.1006/dbio.2002.0636","title":"Deregulated Expression of the Homeobox Gene Cux-1 in Transgenic Mice Results in Downregulation of p27kip1 Expression during Nephrogenesis, Glomerular Abnormalities, and Multiorgan Hyperplasia","year":2002,"lang":"en","type":"article","venue":"Developmental Biology","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; American Heart Association","keywords":"Biology; Transgene; Genetically modified mouse; Epithelium; Endocrinology; Internal medicine; Homeobox; Renal capsule; Renal cortex; Kidney; Cell biology; Gene expression; Molecular biology; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002303397,0.000784368,0.0004630695,0.001325643,0.0003359924,0.0005602433,0.0005147645,0.0006717584,0.001791035],"category_scores_gemma":[0.000229824,0.0005963089,0.0003450405,0.0003973425,0.0008007605,0.0003782443,0.0003338123,0.001374935,0.0005330078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007747831,"about_ca_system_score_gemma":0.0004352296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001013344,"about_ca_topic_score_gemma":0.001840315,"domain_scores_codex":[0.9996276,0.00003754513,0.00003627779,0.0001041311,0.00009725862,0.00009727402],"domain_scores_gemma":[0.9993704,0.00006869337,0.0002810043,0.00005561081,0.00002754059,0.0001967217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001682403,0.00002597936,0.0001583911,0.00001306643,0.0000059961,0.0001471093,0.00001080493,0.00007599124,0.9986044,0.0002427866,0.00003965068,0.0005078237],"study_design_scores_gemma":[0.00003442402,0.00009233419,0.003501451,0.000005104625,0.00002639955,0.0006084408,0.00002410538,0.000743608,0.9939552,0.0001386953,0.0008625331,0.000007625245],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930166,0.001073436,0.003419437,0.0001301453,0.00004001366,0.00002021422,0.0005025006,0.0004795955,0.001317953],"genre_scores_gemma":[0.9901922,0.0006487471,0.002451144,0.00004330373,0.00001708137,0.00003313503,0.0004368828,0.0001528239,0.006024758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001791035,"threshold_uncertainty_score":0.005991578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006582734510261567,"score_gpt":0.1944080821436052,"score_spread":0.1878253476333436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}