{"id":"W2093260892","doi":"10.1006/dbio.2002.0636","title":"Deregulated Expression of the Homeobox Gene Cux-1 in Transgenic Mice Results in Downregulation of p27kip1 Expression during Nephrogenesis, Glomerular Abnormalities, and Multiorgan Hyperplasia","year":2002,"lang":"en","type":"article","venue":"Developmental Biology","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; American Heart Association","keywords":"Biology; Transgene; Genetically modified mouse; Epithelium; Endocrinology; Internal medicine; Homeobox; Renal capsule; Renal cortex; Kidney; Cell biology; Gene expression; Molecular biology; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010591,0.0001437726,0.0001930064,0.00009447818,0.00004755315,0.000002475321,0.0001367622,0.0002745888,0.00001075271],"category_scores_gemma":[0.00001752689,0.0001051223,0.00004455963,0.0001919514,0.000148588,0.000007753955,0.00009416795,0.00008884684,5.861796e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003680455,"about_ca_system_score_gemma":0.00003519702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001021879,"about_ca_topic_score_gemma":0.00008994893,"domain_scores_codex":[0.9988673,0.0001213536,0.0004551121,0.0002834478,0.00007531676,0.0001974979],"domain_scores_gemma":[0.999652,0.00001175061,0.0001442697,0.0001330817,0.00002506478,0.00003382689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002593005,0.0000462031,0.0301528,0.00004168622,0.00001598596,0.00000101648,0.000543565,0.0001330251,0.9678346,0.000001780826,0.00001236308,0.0009576904],"study_design_scores_gemma":[0.0016412,0.00003837229,0.168558,0.0001020574,0.000004388856,0.00002666086,0.0001474968,0.00002641071,0.829166,0.000006629662,0.0001719321,0.0001108415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970444,0.002542938,0.000008200205,0.00004312381,0.00006241442,0.0001891335,0.00003322141,0.00000404201,0.00007256691],"genre_scores_gemma":[0.9977934,0.001435449,0.000548531,0.00001836141,0.00001516464,0.00001106623,0.0001007366,0.00001025758,0.00006703706],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1386686,"threshold_uncertainty_score":0.4286762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006582734510261567,"score_gpt":0.1944080821436052,"score_spread":0.1878253476333436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}