{"id":"W2093264973","doi":"10.1158/0008-5472.can-03-2631","title":"The Histone Deacetylase Inhibitor MS-275 Interacts Synergistically with Fludarabine to Induce Apoptosis in Human Leukemia Cells","year":2004,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute","keywords":"Fludarabine; Histone deacetylase inhibitor; XIAP; Cancer research; Sodium butyrate; Jurkat cells; Histone deacetylase; Apoptosis; Chemistry; Myeloid leukemia; Programmed cell death; Molecular biology; Biology; Caspase; Histone; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001402437,0.0002908864,0.0002718203,0.0003264837,0.0006479912,0.0001495725,0.0008593411,0.0002324412,0.00004797014],"category_scores_gemma":[0.0005414667,0.0002236092,0.00007656093,0.0009508134,0.0007028739,0.0000142866,0.0005450379,0.001085479,0.0001220109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002131844,"about_ca_system_score_gemma":0.001849802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003304321,"about_ca_topic_score_gemma":0.007174536,"domain_scores_codex":[0.996045,0.0003214195,0.0004316311,0.000875238,0.001074025,0.001252681],"domain_scores_gemma":[0.9977154,0.0001128955,0.00005919336,0.0009585968,0.0006354147,0.0005185216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006804315,0.0001284972,0.00002669022,0.00003764111,0.00003260194,0.00004558364,0.0002747734,0.001324038,0.9828247,0.0001941284,0.01332037,0.001110482],"study_design_scores_gemma":[0.001358089,0.0009058195,0.0001564838,0.0002022471,0.000004991216,0.000007605557,0.0001600464,0.000004938617,0.9575561,0.00003714812,0.03932051,0.0002860062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948907,0.0005795505,0.0001153631,0.001940662,0.000183362,0.0008540914,0.00003404269,0.00001976692,0.001382388],"genre_scores_gemma":[0.9942777,0.0002521472,0.0002370191,0.0001805315,0.0005818216,0.0007164889,0.00003746951,0.00008832193,0.003628488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02600013,"threshold_uncertainty_score":0.9118516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02668174598796215,"score_gpt":0.3727006659240568,"score_spread":0.3460189199360946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}