{"id":"W2093264973","doi":"10.1158/0008-5472.can-03-2631","title":"The Histone Deacetylase Inhibitor MS-275 Interacts Synergistically with Fludarabine to Induce Apoptosis in Human Leukemia Cells","year":2004,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute","keywords":"Fludarabine; Histone deacetylase inhibitor; XIAP; Cancer research; Sodium butyrate; Jurkat cells; Histone deacetylase; Apoptosis; Chemistry; Myeloid leukemia; Programmed cell death; Molecular biology; Biology; Caspase; Histone; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009720814,0.0004140413,0.0003754656,0.000250524,0.000117433,0.0002490755,0.0002025884,0.0001804131,0.001238686],"category_scores_gemma":[0.00008616285,0.0001380182,0.0002789103,0.0002024178,0.0001250985,0.0001081176,0.0001850217,0.0002787072,0.0004375185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003647879,"about_ca_system_score_gemma":0.0002749971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001126603,"about_ca_topic_score_gemma":0.002249814,"domain_scores_codex":[0.9998822,0.00002465106,0.000009622151,0.00001596798,0.00003095659,0.00003655026],"domain_scores_gemma":[0.9999615,0.000007650349,0.000007622173,0.000004651403,0.000005891273,0.00001277275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007089791,0.0001032317,0.0003906983,0.0000684288,0.00002080697,0.0001104233,0.0000226548,0.0001977883,0.9948627,0.00007663919,0.0001451935,0.003292422],"study_design_scores_gemma":[0.00009572331,0.001402428,0.004211635,0.000007507253,0.00005108467,0.0003351958,0.00002818378,0.0007842419,0.988934,0.00001993365,0.004124432,0.000005556043],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936917,0.002731493,0.001156381,0.00008365168,0.00003570762,0.00005162337,0.0002107557,0.00008202151,0.001956803],"genre_scores_gemma":[0.9961724,0.001116971,0.0009182316,0.00005182792,0.00001610622,0.00003387618,0.0004541921,0.000008564751,0.001227843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001238686,"threshold_uncertainty_score":0.004143775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02668174598796215,"score_gpt":0.3727006659240568,"score_spread":0.3460189199360946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}